Scientist, Biologics Expression

Takeda Pharmaceuticals; Boston (MA); On-site; USD 111,000 - 176,000; Full time

Job summary

An established industry player is seeking a highly skilled Research Scientist to join their Biologics Generation & Analytics team. This exciting role involves designing and engineering constructs for protein expression, utilizing advanced techniques to enhance therapeutic discovery programs. The ideal candidate will work collaboratively within cross-functional teams, ensuring high-quality protein production and characterization. With a focus on innovation and excellence, this position offers a unique opportunity to contribute to groundbreaking research in biologics. Join a dynamic environment where your expertise will drive significant advancements in therapeutic solutions.

Benefits

Medical Insurance

Dental Insurance

Vision Insurance

401(k) Plan

Tuition Reimbursement

Paid Volunteer Time Off

Paid Vacation

Sick Leave

Short-term Disability

Long-term Disability

Qualifications

• PhD or equivalent in a scientific discipline with strong protein production experience.
• Hands-on experience with high-quality protein production and purification required.

Responsibilities

• Design constructs for protein expression and improve expression performance.
• Perform protein expression using mammalian systems and support downstream processes.

Skills

Protein Production

Protein Characterization

Mammalian Expression Systems

Analytical Skills

Communication Skills

Troubleshooting

Education

PhD in a Scientific Discipline

MS with 6+ years relevant experience

BS with 8+ years relevant experience

Tools

LIMS Systems

High-throughput Automation Systems

WAVE Bioreactor

Job description

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Job Description

Job Description [Research Scientist, Biologics Generation & Analytics]

We are seeking a highly skilled and motivated Research Scientist to join Biologics Generation & Analytics (BGA) group of Global Biologics. The ideal candidate will possess strong background in protein production and characterization using mammalian expression platforms and contribute to antigen and tool molecule production to advance Takeda’s therapeutic discovery programs. A successful candidate will collaborate with matrixed project teams, internal protein production and analytical experts and execute protein production requirements. Effective communication skills and the ability to work within cross-functional teams are essential.

The successful candidate will:

• Design and engineer constructs for protein expression, including reformatting antigens/antibodies and applying advanced protein engineering solutions (innovative non-antibody fusions and different modalities of therapeutics) to improve expression performance.
• Perform protein expression using mammalian expression system, including HEK293 and CHO cell lines at small- to large-scale. The scope of expression work includes the use of high-throughput automation system, shake flasks, to WAVE bioreactor with perfusion setup.
• Support downstream process, including purification and analytical characterization to ensure high-sample quality that fits project needs.
• Evaluate and implement new methods for transient and stable pools on protein expression when appropriate.
• Maintain responsibility for routine laboratory instrumentation and supplies.
• Document experiments thoroughly using LIMS systems and communicate results within the team and cross-functional groups.

Desired qualifications include:

• PhD degree in a scientific discipline (or equivalent), or MS with 6+ years relevant experience, or BS with 8+ years relevant experience. Strong preference for protein production experience in an industry setting.
• Track record of hands-on experience with high-quality protein production (construct design, expression, purification, optimization, characterization) of antigens, antibodies and/or other biologics therapeutics for drug discovery is required.
• Experience in HEK- and CHO-based protein expression (transient and stable) at a variety of scales, including plate-based formats and fermenters or wave bioreactor, is required.
• Experience with antibody purification approaches (including common chromatography), with a track record of being able to adapt these protocols or develop new ones for challenging antibodies and antigens, is highly desirable.
• Strategic experiment planning, data interpretation, summarization, and presentation with minimal supervision are required. Effective verbal and written communication as well as strong interpersonal skills are required.
• Experience managing Co-ops, Research Associates and training fellow scientists is a plus.
• Experience protein production utilizing contract research organizations is a plus.
• Excellent trouble-shooting and organizational skills and attention to details.

For Location: Boston, MA

U.S. Base Salary Range: $111,800.00 - $175,670.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.

The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.