Scientist, Biologics Expression

Lensa; Boston (MA); On-site; USD 111,000 - 176,000; Full time

Job summary

Une entreprise de biopharmaceutique est à la recherche d'un Research Scientist pour rejoindre son équipe. Le candidat idéal aura une solide expérience dans la production de protéines et contribuera à des projets innovants tout en travaillant en étroite collaboration avec d'autres équipes au sein de l'organisation. Ce poste offre des possibilités de développement professionnel et un package de rémunération compétitif.

Benefits

Health insurance

401(k)

Tuition reimbursement

Paid time off

Life insurance

Disability coverage

Qualifications

• Expérience pratique en production de protéines de haute qualité.
• Expérience en expression de protéines HEK et CHO.
• Gestion des Co-ops et formation des scientifiques appréciées.

Responsibilities

• Concevoir et ingénier des constructions pour l'expression de protéines.
• Effectuer des processus de purification et de caractérisation analytique.
• Documenter les expériences en utilisant les systèmes LIMS.

Skills

Communication

Organizational skills

Data interpretation

Troubleshooting

Education

PhD in a scientific discipline

MS with 6+ years of relevant experience

BS with 8+ years of relevant experience

Tools

LIMS systems

Chromatography

Job description

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Job Description

We are seeking a highly skilled and motivated Research Scientist to join the Biologics Generation & Analytics (BGA) group of Global Biologics. The ideal candidate will possess a strong background in protein production and characterization using mammalian expression platforms and contribute to antigen and tool molecule production to advance Takeda’s therapeutic discovery programs. A successful candidate will collaborate with matrixed project teams, internal protein production and analytical experts, and execute protein production requirements. Effective communication skills and the ability to work within cross-functional teams are essential.

The Successful Candidate Will

• Design and engineer constructs for protein expression, including reformatting antigens/antibodies and applying advanced protein engineering solutions (innovative non-antibody fusions and different modalities of therapeutics) to improve expression performance.
• Perform protein expression using mammalian expression systems, including HEK293 and CHO cell lines at small- to large-scale. This includes high-throughput automation, shake flasks, and WAVE bioreactors with perfusion setup.
• Support downstream processes, including purification and analytical characterization to ensure high-quality samples that fit project needs.
• Evaluate and implement new methods for transient and stable pools on protein expression when appropriate.
• Maintain responsibility for routine laboratory instrumentation and supplies.
• Document experiments thoroughly using LIMS systems and communicate results within the team and cross-functional groups.

Desired Qualifications Include

• PhD in a scientific discipline (or equivalent), or MS with 6+ years relevant experience, or BS with 8+ years relevant experience. Industry experience in protein production is preferred.
• Hands-on experience with high-quality protein production (construct design, expression, purification, optimization, characterization) of antigens, antibodies, and/or other biologics therapeutics for drug discovery.
• Experience in HEK- and CHO-based protein expression (transient and stable) at various scales, including plate formats and fermenters or wave bioreactors.
• Experience with antibody purification methods, including chromatography, and ability to adapt or develop protocols for challenging antibodies and antigens.
• Strategic experiment planning, data interpretation, and presentation skills with minimal supervision. Strong communication and interpersonal skills are required.
• Experience managing Co-ops, Research Associates, and training scientists is a plus.
• Experience working with contract research organizations is a plus.
• Excellent troubleshooting, organizational skills, and attention to detail.

Takeda Compensation And Benefits

We offer competitive pay and transparent pay practices. Location: Boston, MA. U.S. salary range: $111,800 - $175,670. Actual salary depends on experience, skills, education, and location. Benefits include incentives, health insurance, 401(k), disability coverage, life insurance, tuition reimbursement, paid time off, holidays, and well-being programs.

EEO Statement

Takeda is committed to creating a diverse workforce and providing equal employment opportunities without regard to race, color, religion, sex, sexual orientation, gender identity, parental status, national origin, age, disability, citizenship, genetic information, marital status, veteran status, or other protected characteristics.

Additional Details

Location: Boston, MA. Worker Type: Employee. Sub-Type: Regular. Time Type: Full-time. Job Exempt: Yes.

In Massachusetts, it is unlawful to require or administer lie detector tests as a condition of employment. Violations may lead to penalties. For questions, contact [e-mail].

Seniority level

• Mid-Senior level

Employment type

• Full-time

Job function

• Research, Analyst, and Information Technology

Industries

• IT Services and IT Consulting