Scientist, Biochemistry I or II

Pacific Biosciences of California; Menlo Park (CA); On-site; USD 97,000 - 168,000; Full time

Job summary

PacBio in the United States is seeking a Scientist, Biochemistry I or II to support commercialization of sequencing platforms. You will produce recombinant proteins to exact specifications and contribute to a quality-assured manufacturing environment in an ISO-regulated setting.

The role requires a MSc in Biochemistry or related field, at least 5 years in Life Sciences, and 3+ years in recombinant protein production.

Qualifications

• MSc in Biochemistry, Protein Chemistry, Molecular Biology or related
• Minimum 5 years in Life Sciences industry
• Minimum 3 years in recombinant protein production, preferably with DNA polymerases
• Experience with affinity chromatography, IEX, HIC, SEC for bacterial expression products
• Experience with automated chromatography systems (AKTA) and analytical methods (HPLC, SDS-PAGE)

Responsibilities

• Design and execute studies to develop robust protein manufacturing processes
• Process protein production orders and manufacture reagents
• Maintain records and production environment per quality standards
• Troubleshoot issues during production and implement corrective actions
• Maintain, qualify and validate equipment as appropriate
• Perform quality control tests and support inventory management
• Collaborate cross-functionally to ensure on-time production builds
• Contribute to development and technology transfer of processes and documentation
• Lead new process development and transfer to production

Skills

Recombinant protein production

Analytical characterization

Team collaboration

Troubleshooting

Process development

Education

MSc in Biochemistry/Protein Chemistry/Molecular Biology

Tools

AKTA chromatography systems

Affinity chromatography

IEX/HIC/SEC

HPLC/Enzyme kinetics

SDS-PAGE

Job description

Scientist, Biochemistry I or IIPacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes, and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health. We are now entering the century of biology and genomics is at the heart of the next revolution. Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team.

Position Summary:

This position will be part of development and manufacturing team to assist commercialization of sequencing platforms. They will be responsible for production of recombinant proteins conforming to product specifications. The ideal candidate would have broad knowledge in protein chemistry/molecular biology, and extensive experience in manufacturing protein products under ISO environment. They will be familiar with analytical tools used for characterization of enzymes, and skilled in troubleshooting and developing corrective solutions. The candidate must have strong collaborative and teamwork attributes.

Responsibilities:

• Design and execute studies to develop and improve robustness of protein manufacturing processes
• Process protein production orders and execute reagent manufacturing activities in a timely manner
• Maintain records and production environment in compliance with quality standards
• Conduct troubleshooting on issues which arise during routine production
• Maintain, qualify, and validate equipment as appropriate
• Perform quality control tests
• Assist in inventory management and ordering materials
• Collaborate cross-functionally to ensure on-time completion of production builds
• Conduct development and technology transfer of reagent manufacturing processes and documentation
• Conduct new process development and transfer to production

Required Qualifications:

• A minimum of MSc degree in Biochemistry, Protein Chemistry, Molecular Biology, or related scientific discipline
• A minimum of 5 years of experience in the Life Sciences industry
• Experience of minimum of 3 years in recombinant protein production, preferably with DNA polymerases
• Experience working with affinity chromatography, IEX, HIC, and SEC, preferably for recombinant protein from bacterial expression system
• Substantial experience with automated chromatography stations such as AKTA systems
• Experience in analytical methodologies for protein characterization including HPLC, enzyme kinetics, protein quantification, spectrophotometer, SDS-PAGE
• Experience in formulation and filtration techniques, such as TFF
• Team player with the ability to take initiative in a fast-paced environment
• Excellent interpersonal, written, and verbal communication skills

Preferred Experience:

• Experience in PLM and ERP systems
• Experience in ISO 9001 and 13485 regulated environments
• Knowledge of Next-Generation Sequencing

Candidates must have current authorization to work in the United States without the need for present or future sponsorship. This role is required to be 100% onsite. You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties. All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.

Salary Range:

$97,400.00 - $168,000.00

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If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at 650-521-8000, or [e-mail] for assistance.

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