Scientist, Antibody Engineering

Joulé; Rockville (MD); On-site; USD 41,328 - 55,104; Part time

Benefits offered by this job

Health and welfare benefits

401(k) participation

Life insurance options

Job summary

A leading biotechnology company is seeking a Scientist Antibody Engineering to join their team in Rockville, MD. This contract role focuses on hands-on contributions to antibody discovery, including phage display, nanobody engineering, and supporting oncology programs. Ideal candidates have extensive experience in molecular biology and are skilled in ELISA and flow cytometry. The position offers competitive compensation in a collaborative research environment.

Qualifications

• 3–5+ years experience with a Bachelor's, or 1–2+ years with a Master's, or recent PhD.
• Direct experience with phage display / bio-panning.
• Strong hands-on experience in molecular biology techniques including cloning and mutagenesis.

Responsibilities

• Contribute to nanobody and antibody discovery and engineering.
• Perform bio-panning of phage libraries to identify lead candidates.
• Design and construct antibody and nanobody constructs using molecular biology techniques.

Skills

Phage display experience

Molecular biology techniques

ELISA and flow cytometry

Attention to detail

Education

Bachelor’s degree in relevant scientific discipline

Master’s degree in relevant scientific discipline

PhD in relevant scientific discipline

Tools

SnapGene

Job description

Job Title: Scientist Antibody Engineering
Location: Rockville, MD (Onsite)
Hours/Schedule: Monday–Friday, 9:00 AM – 5:00 PM
Compensation: $30–$40/hour
Type: Contract (6 months, potential for extension)

Overview

A leading biotechnology company advancing next-generation antibody-based therapeutics is seeking a Scientist / Associate Scientist to join their antibody engineering team. This role focuses on phage display, nanobody/antibody discovery, and bispecific engineering, supporting early-stage oncology programs. This is a highly hands-on opportunity to work on cutting-edge therapeutic platforms in a collaborative research environment.

Responsibilities

• Contribute to the discovery and engineering of nanobodies and antibodies, including bispecific formats
• Perform bio-panning of phage libraries against selected targets to identify lead candidates
• Design, construct, and engineer antibody and nanobody constructs using molecular biology techniques
• Execute PCR, cloning, mutagenesis, RNA isolation, and sequence analysis
• Evaluate antibody/nanobody performance using ELISA, flow cytometry, and Octet
• Analyze binding, function, stability, and developability of candidates
• Support antibody library generation and screening workflows
• Utilize molecular and some computational tools to optimize affinity and stability
• Perform basic data analysis and interpretation of experimental results
• Document experimental procedures and findings in lab notebooks and internal systems
• Collaborate with cross-functional teams to advance discovery programs

Requirements

• Bachelor’s degree with 3–5+ years of experience, OR Master’s with 1–2+ years, OR recent PhD in a relevant scientific discipline
• Direct experience with phage display / bio-panning - required
• Strong hands‑on experience in molecular biology techniques (cloning, mutagenesis, sequencing, plasmid work)
• Experience working with antibody or nanobody libraries is highly desirable
• Hands‑on experience with ELISA and/or flow cytometry for protein/antibody evaluation
• Familiarity with plasmid mapping and sequence analysis tools (e.g., SnapGene)
• Exposure to NGS is a big plus
• Strong attention to detail, documentation skills, and ability to work in a fast‑paced lab environment

Benefits

System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.