Scientist, Antibody Discovery

SystImmune, Inc.; Alderwood Manor (WA); On-site; USD 90,000 - 115,000; Full time

Benefits offered by this job

100% paid employee premiums (medical/d

STD/LTD

401(k) with company match

Job summary

SystImmune, Inc. is seeking a Scientist to advance antibody discovery in a dynamic biopharmaceutical setting. You will design campaigns from immunization to lead delivery and perform high-throughput B-cell sorting, FACS validation, and ELISA/BLI assays to characterize candidates.

The role leverages yeast display libraries and single-cell platforms, with cross-functional collaboration and rigorous data reporting as core duties. Competitive compensation and comprehensive benefits are provided.

Qualifications

• PhD in immunology, molecular biology, biochemistry, or related field.
• 0–2 years of industry experience.
• 3–7 years of hands-on experience in B-cell sorting and screening via flow cytometry, ELISA and bio-layer interferometry.

Responsibilities

• Design and execute antibody discovery campaigns from immunization to lead delivery.
• Perform high throughput sorting to isolate specific B cell populations.
• Design, execute, and analyze FACS experiments to validate and characterize antibodies.
• Develop, optimize, and perform assays (ELISA, BLI, flow cytometry) for antibody screening and specificity testing.
• Conduct yeast display library screening to identify and analyze antibody candidates.
• Analyze experimental data and prepare detailed reports and presentations.
• Work with cross-functional teams and contribute to project planning and strategy.
• Maintain accurate records, ensure safety compliance, and contribute to lab organization.

Skills

Flow cytometry

B-cell sorting

ELISA

Bio-layer Interferometry

Single-cell analysis

Education

Ph.D. in Immunology, Molecular Biology, Biochemistry, or related field

Tools

Sony cell sorters

Bio-layer Interferometry instruments

NGS library prep tools

Job description

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

We are seeking a highly skilled and motivated Scientist to join our Antibody Discovery Group. The successful candidate will play a critical role in advancing our antibody discovery efforts through various techniques, including immunogen design, B-cell sorting, flow cytometry, ELISA, and yeast library screening. This position offers an exciting opportunity to work in a dynamic and innovative environment focused on the development of novel therapeutic antibodies.

Responsibilities

• Design and execute antibody discovery campaigns from immunization to lead delivery.
• Perform high throughput sorting to isolate specific B cell populations.
• Design, execute, and analyze FACS experiments to validate and characterize antibodies.
• Develop, optimize, and perform assays (ELISA, BLI, flow cytometry) for antibody screening and specificity testing.
• Conduct yeast display library screening to identify and analyze antibody candidates.
• Analyze experimental data and prepare detailed reports and presentations.
• Work with cross-functional teams and contribute to project planning and strategy.
• Maintain accurate records, ensure safety compliance, and contribute to lab organization.

Qualifications

• Ph.D. in Immunology, Molecular Biology, Biochemistry, or a related field with 0-2 years of industry experience.
• 3-7 years of hands-on experience in B-cell sorting and screening through flow cytometry, ELISA and bio-layer interferometry.
Proficiency in flow cytometry and cell sorting techniques.
• Experience in biolayer interferometry (affinity, avidity, binning) or similar assays.
• Strong background in ELISA assay development and optimization.
• A proven track record of working with Sony cell sorters or similar instruments is preferred.
• Experience with single-cell analysis platforms (i.e., Beacon) is highly desirable.
• Experience in antibody discovery and development is highly desirable.
• Experience in NGS library preparation and BCR repertoire analysis is a plus.
• Expertise in molecular biology techniques related to yeast display libraries, including preparation, culture and screening is preferred.

Compensation and Benefits

The expected base salary range for this position is $90,000 - $115,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills.

While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.