Scientist, Analytical and Biological Mass Spectrometry (ABMS)

Regeneron Pharmaceuticals, Inc.; Village of Tarrytown (NY); On-site; USD 90,000 - 130,000; Full time

Job summary

Regeneron Pharmaceuticals, Inc. seeks a Scientist in the Analytical and Biological Mass Spectrometry Group to execute LC-MS methods for characterizing biotherapeutic products across drug development stages. You will develop analytical technologies to support diverse R&D programs and ensure robust data generation.

You will work in a fast-paced lab, collaborate with formulation and process teams, and contribute to regulatory filings by producing high-quality reports and SOPs.

Qualifications

• Experience with LC-MS based characterization of protein therapeutics.
• Hands-on with advanced mass spectrometers, LC-MS methods, and data processing.
• Experience with intact mass analysis is a plus.
• Industrial or academic experience in analytical characterization of biotherapeutics preferred.

Responsibilities

• Execute established protocols and communicate analytical characterization of biotherapeutics to support drug development.
• Perform intact-mass LC-MS analyses to elucidate quality attributes such as charge variant and size variant.
• Provide analytical support for cross-functional teams including formulation and process development.
• Independently conduct LC-MS analyses and document procedures in ELN.
• Present data at meetings and write technical reports, SOPs, and regulatory filing reports.

Skills

Mass spectrometry

LC-MS

Analytical method development

Protein therapeutics analysis

Data analysis

Education

Bachelor's or Master's in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences

Tools

LC-MS instruments

Mass spectrometers

ELN software

Job description

Scientist, Analytical and Biological Mass Spectrometry (ABMS)

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a highly motivated Scientist to join the Analytical and Biological Mass Spectrometry Group (ABMS). In this role, you will work in an innovative mass spectrometry lab and execute LC-MS methods for characterizing biotherapeutic products to support all stages of drug development, from early-stage candidate selection to late-stage regulatory submissions. You will develop innovative analytical technologies to support Regeneron’s diverse R&D pipeline.

This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & where:

• Shift Requirements: Full-time
• Location: On-site in Tarrytown, NY

Discover your role:

• Execute established protocols and clearly communicate analytical characterization of biotherapeutics, including monoclonal antibodies, Fc-fusion proteins, and other modalities (antibody-drug conjugates, antibody-oligonucleotide conjugates, adeno-associated virus, siRNA, etc.), to support drug development
• Execute characterization activities, with an emphasis on intact-mass LC-MS technique, to elucidate critical quality attributes such as charge variants, size variants, and post-translational modifications
• Provide analytical support for cross-functional teams, including formulation development, upstream/downstream process development, and manufacturing, to solve drug development challenges
• Independently conduct sample preparation and LC-MS analyses in compliance with SOPs, and document experimental procedures and results in electronic laboratory notebook (ELN)
• Present data at group and project meetings; write technical reports, SOPs, and regulatory filing reports, etc.
• Develop LC-MS based analytical methods to support various R&D programs
• Use strong organization and communication to plan and prioritize work, manage and visualize data, and deliver clear, timely updates
• Bring knowledge and hands‑on experience in LC-MS based analysis of biotherapeutics, including monoclonal antibodies, Fc-fusion proteins, and other modalities (antibody-drug conjugates, antibody-oligonucleotide conjugates, adeno-associated virus, siRNA, etc.)
• Thrive in a fast‑paced, collaborative environment, consistently delivering results with efficiency and ownership
• Quickly learn new technologies, solve complex problems, and demonstrate strong passion for science and innovation
• Be self‑motivated and proactive, with the ability to prioritize effectively and drive work forward with minimal supervision

This role requires:

• Bachelor’s or Master’s degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a closely related field
• Industrial or academic experience in LC-MS based analytical characterization of protein therapeutics
• Hands‑on experience with advanced mass spectrometers, liquid chromatography, various separation technologies, and data processing software is desired
• Experience with intact mass analysis is a plus

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.

Please be advised that at Regeneron, we believe we do our best work when we are together. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Where You'll Make an Impact

Here, you’ll collaborate with teams across regions to help move our mission forward.

We invest in your health and stability so you can focus on making meaningful impact. Below is a highlight of benefit programs that may be available to you, depending on your country of employment, role, etc.

Medical, dental and vision insurance

Life insurance and disability coverage

Global wellness support & benefits access

Paid time off, personal/flexibility hours and holiday leave