Scientist 3, Discovery Oncology

F. Hoffmann-La Roche AG; South San Francisco (CA); On-site; USD 103,000 - 192,000; Full time

Benefits offered by this job

Relocation benefits

Discretionary annual bonus

Benefits package

Job summary

Genentech, a member of the Roche group, seeks a Scientist in Oncology to advance drug discovery through mechanistic experiments in a collaborative setting. You will design and interpret studies, generate robust data, and work across translational disciplines.

PhD in molecular or cancer biology and hands-on expertise in cell culture, genome editing, and pharmacology are required. A strong publication record and teamwork are highly valued.

Qualifications

• Ph.D. in Molecular biology, Cancer biology, or related field.
• M.Sc. with 3+ years of research experience will be considered.
• Deep expertise in mammalian cell culture and advanced cell engineering.
• Hands-on cellular pharmacology and mechanistic assays experience.
• Strong publication or presentation record in industry drug discovery.

Responsibilities

• Design, execute and interpret hypothesis-driven experiments.
• Drive scientific discovery and discuss literature in a fast-paced setting.
• Propose ideas and identify experiments to yield mechanistic insights.
• Collaborate with Drug Discovery, Computational Sciences, and Translational Medicine.
• Share expertise and foster collaborative culture.
• Communicate findings at meetings and cross-functional forums.

Skills

Mammalian cell culture

Cell engineering

CRISPR

Lentiviral delivery

Transposon delivery

Inducible/reporter lines

Cellular pharmacology assays

Dose–response viability

Western blotting

qRT-PCR

Protein interactions/pull-down

Publications / presentations

Collaborative skills

Education

PhD in Molecular biology / Cancer biology

MSc with 3+ years of research experience

Tools

CRISPR-Cas9 gene editing

Lentiviral delivery

Transposon delivery

Inducible/reporter cell lines engineering

Live-cell imaging

High-content imaging

NGS (ATAC-seq, ChIP-seq, RNA-seq)

Job description

The Opportunity We are seeking a talented and highly motivated Scientist to join our Research Oncology team at Genentech. As a Scientist in this role, you will be critical to delivering on our drug discovery pipeline. You will develop projects and design experiments that yield key mechanistic insights to advance novel therapeutic targets and enable new drug discovery approaches. This position offers the opportunity to collaborate with cross-functional teams and utilize cutting-edge technologies to conduct highly impactful and creative research with the ultimate goal of improving patients’ lives.

Key Responsibilities

• Design, execute and interpret hypothesis-driven experiments, generate highly reproducible data robust tools and assays to drive oncology drug discovery forward.
• Drive scientific discovery: Engage in scientific discussion, stay up to date with the scientific literature in a fast-paced dynamic research environment.
• Propose new ideas or creative solutions and identify key experiments to yield key mechanistic insights required to pursue and validate therapeutic targets.
• Collaborate across functions: Work productively with multidisciplinary teams across Genentech, including colleagues in Drug Discovery, Computational Sciences, Translational Medicine, Pathology to support the validation and development of novel therapeutics.
• Foster a collaborative culture by sharing expertise and learning from others.
• Communicate findings: Present and discuss data at regular lab meetings, team meetings, department forums, and cross-functional meetings.

Who You Are

• Ph.D. in the field of Molecular biology, Cancer Biology, or related fields.
• Candidates with an M.Sc. and at least 3 years of research experience will also be considered.
• Possess deep technical expertise in mammalian cell culture (including handling complex or difficult-to-culture models) and advanced cell engineering (CRISPR-Cas9 gene editing, lentiviral/transposon delivery, and generation of inducible or reporter cell lines).
• Demonstrate hands-on mastery in executing cellular pharmacology and mechanistic assays, such as dose-response viability measurements, pathway modulation assays, Western blotting, qRT-PCR, and protein interaction/pull-down assays.
• Bring a proven track record of rigorous, impactful research evidenced by peer-reviewed scientific publications, conference presentations, or documented milestone contributions within an industry drug discovery setting.
• Demonstrate high resilience, self-motivation, and scientific problem-solving capabilities to navigate technical hurdles, with exceptional collaboration skills in team-oriented settings.

Preferred experience

• Strong background in cancer signaling pathways.
• Prior work in hormone-dependent cancers would be a plus.
• Background in transcription factor and chromatin biology, with experience in designing and interpreting NGS experiments (e.g. ATAC-seq, ChIP-seq, RNA‑seq).
• Hands-on proficiency with advanced cellular imaging modalities, including live-cell microscopy, high-content imaging, immunofluorescence (IF), or fluorescence in situ hybridization (FISH) in cell and tissue specimens.

Benefits

Genentech is an equal opportunity employer.

It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence.

The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

• Relocation benefits are available for this job posting.
• A discretionary annual bonus may be available based on individual and Company performance.
• This position also qualifies for the benefits detailed at the link provided below.

Genentech is an equal opportunity employer.

It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence.

The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases.

To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society.

Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

The next step is yours.

Also in your compensation, the expected salary range for this position based on the primary location of South San Francisco, CA is $103,400 to $192,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.

A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.