Scientist #26-27210

US Tech Solutions; South San Francisco (CA); Vor Ort; USD 55.000 - 83.000; Vollzeit

Zusammenfassung

US Tech Solutions seeks a contract scientist to join its R&D imaging team. You will support high-content imaging projects, culture mammalian cells, develop assays, and perform fluorescence microscopy with quantitative analysis.

Ideal candidates have hands-on culture skills, experience in image analysis, and comfort troubleshooting bench experiments. Training on Opera Phenix and workflows will be provided as needed.

Qualifikationen

• Hands-on mammalian cell culture and cell-based assays.
• Fluorescence microscopy and quantitative image analysis experience.
• Immunofluorescence staining or live-cell imaging experience.
• Experience with primary cells or co-culture systems is a plus.
• High-content imaging platforms like Opera Phenix are a plus but not required.
• Automation, robotics, or screening workflow familiarity is beneficial.

Aufgaben

• Maintain mammalian cell cultures and prepare samples for imaging.
• Develop, optimize, and execute image-based cellular assays.
• Perform fluorescence microscopy and automated imaging experiments.
• Collaborate with R&D and assist experimental design and analysis.
• Develop quantitative image analysis workflows (Fiji/ImageJ, Imaris, etc.).
• Analyze, document, and communicate experimental results.
• Contribute to research on immune synapses and T-cell engagers.
• Operate and maintain Opera Phenix instrumentation and automation.
• Troubleshoot imaging and sample-prep issues with the team.
• Help train scientists on imaging and analysis tools.
• Work with imaging scientists and biologists across R&D.
• Learn and adopt new microscopy and automation technologies.

Kenntnisse

Mammalian cell culture

Cell-based assays

Microscopy & image analysis

Ausbildung

BS/MS/PhD in cell biology/immunology/biomedical sciences

Tools

Opera Phenix

Fiji/ImageJ

Imaris

CellProfiler

Jobbeschreibung

Duration: 12 months contract Shift: Preferably 8:30 AM - 5:30 PM PST

Job Details:

• We are seeking a motivated and collaborative contract scientist to join an R&D imaging and image analysis team supporting research programs across multiple therapeutic and functional areas. Our group operates a high-content imaging core and partners with scientists throughout R&D to develop and execute imaging-based assays and enable quantitative cellular research.
• The successful candidate will be a strong experimentalist with hands-on experience in mammalian cell culture, cellular assay development and sample preparation.
• Previous microscopy and image analysis experience is important, but extensive experience with high-content imaging or specialized imaging techniques is not required. We are particularly interested in candidates who are comfortable at the bench, enjoy troubleshooting biological assays, and are eager to learn new imaging and quantitative analysis approaches.
• The scientist will contribute to both core imaging activities and collaborative research projects. Current research within the group includes quantitative imaging of immune synapse formation and other cell-cell interactions relevant to the development and characterization of T-cell engagers.
• Our imaging core includes two automated Opera Phenix high-content imaging systems integrated with robotic plate handling, incubators, and scheduling software. Training on these systems and associated workflows will be provided.
• Above all, we are looking for a strong experimental scientist who enjoys working at the bench, approaches experiments thoughtfully and is curious about imaging and quantitative biology.
• The ideal candidate does not need to arrive as an expert in high-content imaging. We value someone who can generate high-quality biological samples and assays, troubleshoot experiments independently, collaborate effectively with other scientists, and is enthusiastic about developing deeper expertise in imaging and image analysis.

Preferred Qualifications:

• BS or MS or Ph.D. in cell biology, immunology, bioengineering, biochemistry, biomedical sciences, or a related discipline, with relevant laboratory experience.
• Strong hands-on experience with mammalian cell culture and cell-based assays.
• Experience with fluorescence microscopy and quantitative image analysis.
• Experience with immunofluorescence staining, live-cell imaging, or other microscopy sample-preparation techniques.
• Experience with primary cells, immune cells, co-culture assays, or cell-cell interaction assays is a plus.
• Experience with high-content imaging platforms such as the Opera Phenix is a plus but is not required.
• Experience with automated laboratory workflows, robotic plate handling, or screening environments is beneficial but not required.
• Familiarity with Fiji/ImageJ, Imaris, CellProfiler, Harmony, or related image analysis tools is desirable.
• Programming experience in Python, R, MATLAB, or similar environments is a plus but is not required.

Key Responsibilities:

• Maintain mammalian cell cultures and prepare cells and samples for imaging experiments.
• Develop, optimize, and execute image-based cellular assays, including co-culture and cell-cell interaction assays.
• Perform fluorescence microscopy and automated imaging experiments.
• Support imaging studies conducted in collaboration with scientists across R&D, from experimental design and sample preparation through image acquisition and analysis.
• Develop and apply quantitative image analysis workflows using tools such as Fiji/ImageJ, Imaris, high-content analysis software, or other computational approaches.
• Analyze, interpret, document, and communicate experimental results.
• Contribute to research focused on immune synapses, cell-cell contacts, and other imaging-based approaches relevant to T-cell engager research.
• Assist with operation and routine maintenance of automated high-content imaging instrumentation, including Opera Phenix systems and associated automation.
• Troubleshoot imaging, assay, and sample-preparation issues and work with team members to identify practical solutions.
• Help maintain robust and reproducible imaging workflows, protocols, and documentation.
• Support and, with experience, help train scientists using imaging instrumentation and analysis tools.
• Work collaboratively with imaging scientists, biologists, and project teams across different areas of R&D.
• Learn and adopt new microscopy, automation, assay-development, and image-analysis technologies as needed.

Top 3 Must Have Skill Sets:

• Strong mammalian cell culture and experimental skills: Hands-on experience culturing mammalian cells and performing cell-based experiments. The candidate should demonstrate excellent sterile technique, attention to experimental quality and reproducibility, and the ability to troubleshoot cell-based assays. Experience working with primary cells, immune cells, or co-culture systems is desirable but not required.
• Cell-based assay development and sample preparation: Experience developing, optimizing, or executing cellular assays, including preparation of samples for microscopy or other quantitative readouts. The ideal candidate understands how experimental variables—including cell density, timing, treatments, staining, controls, and sample handling—affect assay performance and data quality.
• Microscopy and quantitative image analysis experience: Hands-on experience with fluorescence microscopy and at least one image analysis platform or approach, such as Fiji/ImageJ, Imaris, CellProfiler, commercial imaging software, or custom computational workflows. Experience with automated or high-content imaging is beneficial but not required. More important is an interest in quantitative imaging and a willingness to learn new imaging and analysis technologies.

About US Tech Solutions:

US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit www.ustechsolutions.com.

US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

AI Statement:

By applying, you acknowledge that AI-assisted tools may be used during hiring.

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