Scientist 1, Oligonucleotide Chemist (Synthesis & Purification)

biomarin; San Rafael (CA); On-site; USD 110,000 - 170,000; Full time

Job summary

BioMarin is seeking a dedicated Scientist specializing in oligonucleotide synthesis in San Rafael, CA. You will join a multidisciplinary team to advance nucleic acid‑based therapeutics and develop robust synthesis and purification workflows.

The role emphasizes collaboration, precise data handling, and a commitment to safety and regulatory compliance within a cutting‑edge biotech environment.

Qualifications

• PhD in Chemistry with 0–2 years of industry experience, or Master’s with 8–10 years in biotech/pharma.

Responsibilities

• Collaborate with project teams to advance research and new methodologies.
• Work with bioconjugation chemists, biologists, and other specialists.
• Perform oligonucleotide synthesis using automated solid‑phase methods.
• Purify oligos via HPLC and related techniques to meet purity standards.
• Maintain thorough records of protocols, results, and analyses.
• Support a safe, compliant laboratory environment.

Skills

Independent work

Team collaboration

Scientific communication

Oligonucleotide synthesis

Education

PhD in Chemistry (0-2 yrs industry)

Job description

Overview

BioMarin is seeking a dedicated and skilled Scientist specializing in oligonucleotide synthesis to contribute to our cutting‑edge research and development efforts in nucleic acid‑based therapeutics. This role offers a unique opportunity to be part of a dynamic team at the forefront of biotechnology innovation, working on projects that have the potential to transform patient outcomes.

Key Responsibilities

• Engage actively in project team discussions across the organization, providing subject‑matter expertise to support the progression of research projects and the development of new methodologies.
• Work synergistically with multidisciplinary teams, including bioconjugation specialists, chemists, and biologists, to drive project success and foster a collaborative research environment.
• Execute oligonucleotide synthesis utilizing automated solid‑phase synthesis methodologies to ensure high‑quality and reproducibility of synthesized oligonucleotides.
• Conduct purification of synthesized oligonucleotides via high‑performance liquid chromatography (HPLC) and other relevant techniques to achieve the desired purity and quality standards.
• Maintain comprehensive and meticulous records of experimental protocols, results, and data analyses, ensuring data integrity and compliance with regulatory standards.
• Contribute to the maintenance of a safe and compliant working environment, adhering to all health and safety regulations and promoting a culture of safety within the laboratory.

Education & Requirements

• PhD degree in Chemistry with 0‑2 years of industry experience, or Master’s degree with 8‑10 years in the biotech or pharmaceutical industry.

Skills

• Demonstrated ability to work independently as well as part of a collaborative team environment, with a proactive approach to problem‑solving and advancing research programs.
• Strong enthusiasm for scientific research and innovation, coupled with excellent organizational skills and the ability to manage multiple tasks and projects simultaneously.
• Commitment to maintaining up‑to‑date knowledge of advancements in oligonucleotide chemistry and related fields, with a willingness to engage in ongoing professional development.
• Expertise in solid‑phase oligonucleotide synthesis and purification, with a strong track record of successful project outcomes.
• Excellent written and verbal communication skills, with the ability to effectively present data and findings to both technical and non‑technical audiences.

Work Style

• This is an onsite daily role in San Rafael, CA.
• This role will have a daily presence in our Research labs executing experiments.

This position represents an exciting opportunity to contribute to BioMarin's mission of developing innovative therapies for patients with serious and life‑threatening conditions. We look forward to welcoming a passionate and skilled oligonucleotide chemist to our team.

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.