Scientist

Spectraforce Technologies; Worcester (MA); On-site; USD 55,000 - 83,000; Full time

Job summary

Spectraforce Technologies is seeking a Scientist for a 4-month on-site opportunity in Worcester, MA. The role supports the Analytical Development team at the Client's Bioresearch Center, developing and executing analytical methods for biologics from discovery through commercial stages.

You will contribute to LC-MS, HPLC/UPLC, protein characterization, and biophysical analyses, collaborating with the Analytical Characterization Group to drive method development and data integrity.

Qualifications

• Bachelor's or Master’s degree in a chemistry/biology/biochemistry or related field with relevant biotech/pharma experience.
• Hands-on protein mass spectrometry, liquid chromatography, and protein biophysical characterization.
• Familiarity with HPLC or AKTA instrumentation.
• Fundamental understanding of protein structure and post-translational modifications.
• Proficient with Windows 10 and Microsoft Office; strong written and oral communication.

Responsibilities

• Perform mass spectrometry analyses (intact/reduced mass, peptide mapping) of biologics to verify sequence and PTMs.
• Independently operate separation methods (fractionation & analysis) using HPLC and AKTA.
• Conduct biophysical measurements (e.g., DSC) to support characterization studies.
• Design and execute method development or investigations; document results in ELN.
• Support process development with raw material analysis using vibrational spectroscopy and metabolomics MS.
• Generate precise, reliable data and communicate findings timely.
• Draft protocols, method development reports, and technical characterization reports.
• Maintain laboratory equipment and ensure safety/compliance.

Skills

Separation assays (HPLC/UPLC)

LC-MS of proteins

Understanding protein structure & PTMs

Written & verbal communication

Hardworking & motivated

Education

BS in chemistry/biochem or related field

MS in related field (preferred)

Tools

AKTA chromatography

HPLC/UPLC instruments

LC-MS instrumentation

Vibrational spectroscopy (IR/NIR/Raman) knowledge

Job description

Duration: 04 months (could be extended)
Location: Worcester, MA; 01604- 100% On-site

Job Title: Scientist

Duration: 04 months (could be extended)
Location: Worcester, MA; 01604- 100% On-site

Description:

We are searching for a highly motivated Scientist to join our Analytical Development team at the Client's Bioresearch Center in Worcester, MA. Our team is responsible for the development, qualification, and execution of analytical methods to provide product and process understanding for biological entities from discovery through commercial stages.

As a Scientist, you will be a part of the Analytical Characterization Group (ACG) within the Analytical Development Department. ACG focuses on providing routine, investigative, and in-depth characterization analyses of Client's biologics to support product and process development for early-phase, late-phase, and commercial programs using liquid chromatography mass spectrometry (LC-MS), spectroscopy and various other biophysical assays.

The successful candidate will contribute to the development and performance of analytical assays and will contribute to the continuous improvement and innovation within ACG and the Analytical Development Department.

What are the top 3-5 skills, experience or education required for this position:

• 1.Perform separation assays such as HPLC/UPLC chromatography
• 2.Perform fractionation using AKTA
• 3.Perform LC-MS experiments on intact protein
• 4.Fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein characterization
• 5. Excellent written communication, oral communication, organization, and multitasking skills

Key Responsibilities:

• Perform mass spectrometry analyses (i.e., intact/reduced mass analysis by LC-MS and peptide mapping by LC-MS) of Client's biologics to provide sequence verification and post-translational modification profiles.
• Independently perform separation methods (e.g., fractionation & analysis of variants) using HPLC and AKTA
• Perform biophysical methods (e.g., DSC) of Client's biologics to support characterization studies.
• Design and execute experiments for method development and/or investigations.
• Support process development by performing raw material analysis using vibrational spectroscopy and executing metabolomics experiments using mass spectrometry.
• Generate and communicate precise, reliable, and reproducible data in a timely manner.
• Organize and document experiments and results in an electronic laboratory notebook.
• Draft protocols, method development reports, and technical characterization reports.
• Maintain lab equipment.

Qualifications:

• Bachelors or Masters in chemistry, biology, biochemistry or related technical discipline with typically 5+ (BS) or 2+ (MS) years of relevant experience in biotech/pharmaceutical industry setting.
• Hands-on experience with protein mass spectrometry, liquid chromatography, capillary electrophoresis and protein biophysical characterization.
• Knowledge of HPLC or AKTA instrumentation
• Fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein characterization.
• Working knowledge of bioinformatics tools to process and analyze mass spectrometry data is highly desirable.
• Knowledge of vibrational spectroscopy (e.g., IR, NIR and Raman) and multivariate analysis is desirable.
• Proficient with Windows 10 and Microsoft Office (Outlook, Excel, Word, and PowerPoint).
• Excellent written communication, oral communication, organization, and multitasking skills.
• Hardworking and motivated to drive both efficiency and quality.
• Understand and adhere to corporate standards regarding code of conduct, safety, and appropriate handling of materials.

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