Scientific Manager, Translational Biology, CVRM

Genentech; San Francisco (CA); On-site; USD 116,000 - 215,000; Full time

Benefits offered by this job

Relocation assistance

Job summary

Genentech is seeking a highly motivated PhD-level scientist in the CVRM Translational Biology group to lead pharmacology efforts that drive drug discovery and development. The role involves designing mechanistic studies, evaluating literature and novel assays, and working closely with a multidisciplinary team to accelerate programs.

Key responsibilities include mentoring junior scientists, overseeing CRO studies, and contributing to regulatory submissions while advancing cardio-metabolic

Qualifications

• PhD in Pharmacology, Biology or related field with 3+ years post‑graduate experience
• Knowledge in cardio-metabolic disease field with strong in‑vivo background
• Hands‑on experience with cardiovascular models and phenotyping (echo, catheterization) to inform CVRM biology and drug discovery
• Leader from the bench with ability to mentor others
• Multitask effectively and communicate across multidisciplinary teams

Responsibilities

• Provide scientific and technical hands‑on support for in vivo and ex vivo studies in cardiovascular, renal, obesity, and metabolic models to advance drug candidates
• Plan and execute experiments, develop protocols, document data, troubleshoot problems, interpret data and communicate results
• Advise on technical or project strategy as appropriate
• Mentor and train junior members to be scientifically proficient
• Manage CRO studies, evaluate data, and assist with regulatory submissions documents
• Collaborate within multidisciplinary project teams and communicate timelines and results

Skills

PhD in Pharmacology

In vivo expertise

Cardio-metabolic focus

Project leadership

Team collaboration

Education

PhD in Pharmacology or related field

Tools

Echocardiography equipment

Job description

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech!

The Opportunity

The CVRM (Cardiovascular, Renal, and Metabolism) Translational Biology group within Genentech Research and Early Development (gRED) is seeking a highly motivated and well-trained individual to lead the pharmacology efforts to drive drug discovery and therapeutic development, and design and execute mechanistic studies to characterize these compounds and their impact on physiology and pathophysiology. In addition, you will help evaluate literature information and novel assay formats to ensure rapid progress and overall project success. This position requires working closely with scientists in a multidisciplinary team. Our environment is exciting and fast paced, requiring you to be excellent at multitasking and easily adaptable to meet evolving goals. This is an exciting opportunity to join a growing CVRM biology group and make significant contributions.

Primary Responsibilities

• Provide scientific and technical hands‑on support for research involving but not limited to in vivo and ex vivo studies in animal models of cardiovascular, renal, obesity, and metabolic conditions with the goal of progressing novel drug candidates into clinical development and beyond.

• Plan and execute experiments, develop and follow protocols, document data, troubleshoot problems, interpret data and communicate results, and maintain up‑to‑date knowledge in the fields.

• Advise on technical or project strategy as appropriate

• Mentor and train junior members to be scientifically and technically proficient.

• Manage studies performed at CROs, evaluate the resulting data, develop technical documents and assist with the preparation and/or review of information supporting regulatory submissions.

• Work collaboratively within multidisciplinary project teams.

• Effectively communicate lab activities, timelines and results to team members and collaborators.

Who You Are

• PhD in Pharmacology, Biology or other related field with 3 + years relevant post‑graduate experience.

• Knowledge in the cardio‑metabolic disease field with a strong in‑vivo background is essential.

• Hands‑on experience with cardiovascular models (heart and kidney ischemia reperfusion injury, transverse aortic constriction) and phenotyping (echocardiography, heart catheterization) to answer questions about CVRM biology and drug discovery.

• A scientist with passion for hands‑on research and desire to lead from the bench.

• Ability to multitask and contribute to several projects while remaining well organized.

• Ability to take unique and creative approaches to solve challenging problems.

• Good interpersonal skills and ability to work well with a multidisciplinary team and effectively communicate in cross‑functional forums.

Preferred

• Experience in rodent surgeries (in addition to cardiovascular), ex vivo experiments, and isolation of primary cells is a plus.

• Prior experience working in a biotech or pharmaceutical industry setting, understanding the demands and timelines of a drug discovery and development environment.

Relocation benefits are available for this job posting.

The expected salary range for this position based on the primary location of South San Francisco, CA is $115,900 to $215,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job‑related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.