RNAi Formulations Scientist I – Preclinical Delivery

GForce Life Sciences; Lexington (MA); On-site; USD 90,000 - 120,000; Full time

Job summary

GForce Life Sciences in Lexington, MA seeks a Research Scientist specializing in RNAi formulations. You will perform hands-on formulation development, biophysical characterization, and analytical testing to support preclinical RNAi and oligonucleotide projects.

The role requires strong experimental planning, data analysis, documentation, and the ability to work with cross-functional teams under tight timelines. A PhD or MS with relevant experience is preferred.

Qualifications

• MS with 3 years of relevant experience or PhD with 1–3 years in pharmaceutical sciences, formulation sciences, chemical engineering, biophysics, analytical chemistry, oligonucleotide delivery, or related discipline.
• Hands-on experience with oligonucleotide or antibodies/proteins formulation and characterization is strongly preferred.
• Experience developing or running analytical methods for solubility, viscosity, osmolality, aggregation, stability, or developability assessments for complex formulations.
• Familiarity with automation, high-throughput screening, and DoE-based optimization is advantageous.
• Strong experimental planning, documentation, data analysis, and problem-solving skills.

Responsibilities

• Support development and characterization of preclinical RNAi and oligonucleotide formulations across portfolios and projects.
• Perform hands-on formulation preparation, biophysical characterization, analytical testing, and data analysis to aid formulation selection.
• Establish screening assays for oligonucleotides in early discovery, including solubility, viscosity, osmolality, degradation, and stability.
• Contribute to high-throughput and DoE-based formulation optimization where applicable.
• Support storage and stability evaluations for RNAi conjugates and formulations.
• Maintain rigorous experimental documentation and present findings through summaries, reports, and presentations.
• Collaborate with internal and external partners to meet project deliverables and timelines.
• Identify gaps and propose practical improvements to workflows.

Skills

Oligonucleotide formulation

Antibody/Protein formulation

Analytical method development

Experimental planning

Education

MS with 3 years experience

PhD with 1-3 years experience

Tools

Automation

High-throughput screening

DoE formulation optimization

Job description

GForce Life Sciences in Lexington, MA seeks a Research Scientist specializing in RNAi formulations. You will perform hands-on formulation development, biophysical characterization, and analytical testing to support preclinical RNAi and oligonucleotide projects.

The role requires strong experimental planning, data analysis, documentation, and the ability to work with cross-functional teams under tight timelines. A PhD or MS with relevant experience is preferred.