Researcher 2- Neurology

The Ohio State University; Columbus (OH); On-site; USD 70,000 - 110,000; Full time

Job summary

The Ohio State University is seeking a Researcher 2 in Neurology within the PIIO at OSUCCC-James. The role focuses on studying how the neuro-immune axis shapes anti-tumor immunity and identifying biomarkers and therapeutic targets.

Under Dr. Acharya, you will apply advanced techniques such as multiparameter flow cytometry, CRISPR-Cas9, scRNA-seq, and imaging to advance immuno-oncology research. Mentorship and training of staff are integral to the position.

Qualifications

• Master's Degree or equivalent experience required; 3 years of relevant experience with Bachelor's, or 1 year with Master's.
• PhD in Biochemistry or related field required; extensive mouse model experience desirable.

Responsibilities

• Execute research projects using high-dimensional flow cytometry, CRISPR-Cas9, scRNA-seq and bulk RNA-seq.
• Collaborate with the PI to analyze data, compile results, and prepare reports, manuscripts, and grant submissions.
• Train research staff in basic and advanced lab techniques and perform routine animal procedures.

Skills

High-dimensional flow cytometry

CRISPR-Cas9

Single-cell RNA sequencing

Bulk RNA sequencing

Multispectral imaging

Immunohistochemistry

Western blotting

Tissue culture

Genotyping

qPCR

Education

Master's degree or equivalent experience

PhD in Biochemistry or relevant field

Tools

Flow cytometry

CRISPR-Cas9

scRNA-seq

bulk RNA-seq

Multispectral imaging

Immunohistochemistry

Job description

Job Title: Researcher 2 - Neurology

Department: Medicine | Neurology

Scope/Summary:

A Researcher 2 position is available in the laboratory of Dr. Acharya, in the Ohio State University Comprehensive Cancer Center (OSUCCC) Pelotonia Institute for Immuno-Oncology (PIIO). The laboratory of Dr. Acharya studies how cellular and molecular determinants in the neuro-immune axis influence cancer initiation, progression, and metastasis. She is also researching the role of neuro-immune crosstalk and how this process shapes anti-tumor immune responses. This work will significantly increase our understanding of how tumors develop and grow, help to identify new biomarkers for cancer diagnosis, and define novel targets for therapeutic interventions. The Researcher 2 will be integrated into a highly collaborative and dynamic immuno-oncology research environment at the Pelotonia Institute for Immuno-Oncology (PIIO), with access to state-of-the-art facilities and technologies. The Researcher 2 will execute research projects using techniques such as high-dimensional multiparameter flow cytometry, CRISPR-Cas9, single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing (RNA-seq), multispectral imaging, immunohistochemistry, Western blotting, tissue culture, genotyping, and qPCR. Under the guidance of Dr. Acharya, the Researcher 2 will conduct specialized research aimed at identifying novel therapeutics that can synergize with existing immunotherapy modalities. The Researcher 2 will collaborate with the principal investigator in analyzing and interpreting research data, compiling results, and preparing reports, manuscripts, and grant submissions. The Researcher 2 will also participate in training research staff in both basic and advanced laboratory techniques and perform routine laboratory animal procedures.

Minimum Qualifications:

Master's Degree or equivalent experience required; 3 years of relevant experience required with Bachelor's Degree, or 1 year of relevant experience required with Master's Degree.

Preferred Qualifications:

A Ph.D. in Biochemistry or other relevant field is required. Extensive experience with mouse models is desirable, including preparation of pre-operative brain tumor cell suspensions, stereotactic orthotopic xenograft implantation of brain tumors in mice, and use of bioluminescent imaging to monitor tumor growth and response to therapy. Strong publication record is desired. Ability to write up project findings and draft proposals and manuscripts for publication is desired. The university requires completion of a background check and qualified candidates may be asked to complete a pre-employment physical including a drug screen.

Career Roadmap:

FUNCTION: Research and Scholarship

SUB-FUNCTION: Research

CAREER BAND: Individual Contributor - Specialized

CAREER LEVEL: S2

Additional Information:The OSUCCC – James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities. The Pelotonia Institute for Immuno-Oncology (PIIO) is a comprehensive bench-to-bedside research initiative focused on harnessing the body’s immune system to fight cancer at all levels - from prevention to treatment and survivorship. The Laboratory of Dr. Acharya is a part of the OSUCCC-James, PIIO. Dr. Acharya’s research focuses on comprehensive understanding of the tumor microenvironment that will aid the development of holistic therapeutic strategies for the treatment of cancer.

Location: Biomedical Research Tower (0112)

Position Type: Regular

Scheduled Hours: 40

Shift: First Shift

Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.

The university is an equal opportunity employer, including veterans and disability.