Research Technician II- Cheng Lab

ccf; Cleveland (OH); On-site; USD 52,000 - 72,000; Full time

Job summary

Cleveland Clinic's Genome Center is seeking a Research Technician II to support daily research activities under Dr. Feixiong Cheng. The role involves cell culture, sequencing workflows, and lab operations across functional genomics and disease modeling projects.

You will gain exposure to cutting-edge techniques and contribute to funded projects that advance human health, within a world-class healthcare system that emphasizes excellence and patient care.

Qualifications

• Minimum: High School Diploma or GED with four years of lab experience.
• Minimum: Associate's degree in laboratory science with three years of experience.
• Minimum: Bachelor's degree with two years of experience.
• Minimum: Master's degree with one year of experience.

Responsibilities

• Participate in daily research project activities.
• Plan, organize, perform and monitor daily project protocols.
• Collect, prepare and maintain required research documentation, including informed consent records, case records, clinical notes and medical reports.
• Report and assist with managing protocol deviations, adverse events and other project-related issues.
• Be responsible for the general maintenance and upkeep of the lab.
• Order and purchase supplies, gather information on new equipment and recommend purchases.
• Assist with cell culture, including maintenance of iPSC-derived neurons, microglia, astrocytes, and/or brain organoids.
• Support experiments in functional genomics such as CRISPR/Cas9 or CRISPRi/a workflows, Basic molecular biology (PCR, cloning, DNA/RNA extraction) and Next-generation sequencing (NGS) library preparation.
• Perform sample processing, reagent preparation, buffer making, and general laboratory organization.
• Assist with FACS sample preparation, immunostaining, and microscopy as needed.
• Maintain detailed and accurate experimental records in lab notebooks and electronic databases.
• Follow standard operating procedures, safety guidelines, and quality control measures.

Education

High School Diploma or GED

Associate's degree in laboratory science

Bachelor's degree

Master's degree

Tools

Flow Cytometer

PCR

NGS library preparation

Job description

Job Title

Research Technician II- Cheng Lab

Location

Cleveland

Facility

Cleveland Clinic Main Campus

Department

LRI Genomic Medicine Institute-Research Innov and Educ

Job Code

D99981

Shift

Days

Schedule

8:30am-5:00pm

At Cleveland Clinic Health System, we believe in a better future for healthcare. And each of us is responsible for honoring our commitment to excellence, pushing the boundaries and transforming the patient experience, every day.

We all have the power to help, heal and change lives - beginning with our own. That's the power of the Cleveland Clinic Health System team, and The Power of Every One.

Join Cleveland Clinic's Main Campus where research and surgery are advanced, technology is leading-edge, patient care is world class and caregivers are family. Here, you will work alongside a passionate and dedicated team, receive endless support and appreciation, and build a rewarding career with one of the most respected healthcare organizations in the world.

As a Research Technologist, you will participate in the design, organization, and execution of daily research activities within the Cleveland Clinic Genome Center, directed by Dr. Feixiong Cheng, to support experimental research in functional genomics, stem cell-based disease modeling, and molecular biology. The lab supports a large and growing portfolio of sponsored projects, all of which require sustained, hands-on work in cell culture, sample preparation, sequencing workflows, and overall laboratory operations. Candidates gain exposure to cutting edge functional genomics and disease modeling, contribute to long-term funded projects, and play a meaningful role in discoveries that translate to human health, directly supporting Cleveland Clinic's mission to advance patient care through high-impact biomedical research.

Read more about Dr. Cheng's lab: https://www.lerner.ccf.org/genomic-medicine/cheng/

A caregiver in this role works days from 8:30 a.m. - 5:00 p.m. (flexible start/end times)
Occasional weekend shifts are required.

Responsibilities

• Participate in daily research project activities.
• Plan, organize, perform and monitor daily project protocols.
• Collect, prepare and maintain required research documentation, including informed consent records, case records, clinical notes and medical reports.
• Report and assist with managing protocol deviations, adverse events and other project-related issues.
• Be responsible for the general maintenance and upkeep of the lab.
• Order and purchase supplies, gather information on new equipment and recommend purchases.
• Assist with cell culture, including maintenance of iPSC-derived neurons, microglia, astrocytes, and/or brain organoids.
• Support experiments in functional genomics such as CRISPR/Cas9 or CRISPRi/a workflows, Basic molecular biology (PCR, cloning, DNA/RNA extraction) and Next-generation sequencing (NGS) library preparation.
• Perform sample processing, reagent preparation, buffer making, and general laboratory organization.
• Assist with FACS sample preparation, immunostaining, and microscopy as needed.
• Maintain detailed and accurate experimental records in lab notebooks and electronic databases.
• Follow standard operating procedures, safety guidelines, and quality control measures.

Minimum qualifications

• High School Diploma or GED and four years of experience in a research or related laboratory environment
• Associate's degree in laboratory science and three years of experience
• Bachelor's degree and two years of experience
• Master's degree and one year of experience

Preferred qualifications

• Bachelor's or Master's degree
• Hands-on experience in cell culture, molecular biology techniques, sample preparation, and laboratory organization
• Comfortable executing routine and semi-technical experiments independently
• Strong time management, documentation skills
• Ability to work in a fast-paced research environment

Physical Requirements

• Ability to perform work in a stationary position for extended periods
• Ability to operate a computer and other office equipment
• Ability to communicate and exchange accurate information
• Ability to distinguish color
• Manual dexterity to handle specimens and repair equipment
• Ability to lift and transport equipment or specimens weighing up to 20 pounds
• May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.

Personal Protective Equipment

Follows standard precautions using personal protective equipment as required.

The policy of Cleveland Clinic Health System and its system hospitals (Cleveland Clinic Health System) is to provide equal opportunity to all of our caregivers and applicants for employment in our drug free environment. All offers of employment are followed by testing for controlled substances.

Cleveland Clinic Health System administers an influenza prevention program. You will be required