Research Scientist/Engineer Assistant

UW Advancement Careers; Seattle (WA); On-site; USD 56,000 - 71,000; Full time

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Job summary

UW Advancement Careers in Seattle seeks a Research Scientist/Engineer Assistant to apply biochemistry and protein design to cancer immunotherapy. The role centers on designing de novo proteins and binding molecules using on-site computational pipelines, collaborating with the biochemistry lab.

The candidate will read literature on cancer and immune targets, present findings in weekly lab meetings, and document workflows for reproducible design work. A Bachelor's degree is required.

Qualifications

• Bachelor's Degree in Biology, Computer Science, or related disciplines.
• Less than one year of relevant experience.
• Equivalent education and/or experience may substitute for minimum qualifications.

Responsibilities

• Design de novo proteins against biological targets.
• Design binders using computational pipelines (RF Diffusion, Protein MPNN, RF3) for cancer/immune targets.
• Study immune cell biology behind chosen targets and relevance to cancer immunotherapy.
• Present work in weekly lab meetings and discuss literature.
• Document workflows for computational pipelines to aid future work.

Skills

Python

Protein design

Cell biology

Immunology

Education

Bachelor's Degree in Biology, Computer Science, or related disciplines

Job description

Job Description

The Department of Biochemistry has an outstanding opportunity for a Research Scientist/Engineer Assistant.

About This Opportunity

Applying biochemistry and protein design for cancer immunotherapy. We will use protein design to systematically modulate T cells to improve immune cell behavior in the context of cancer immunotherapy.

Major Duties And Responsibilities

• Designing de novo proteins against various biological targets: 60%
• Use computational pipelines including RF Diffusion, Protein MPNN, and RF3 to design binders against cancer and immune targets (including phosphatases, transcription factors, and others that are therapeutically relevant). This will be done using computational tools that are developed at the Institute for Protein Design. The candidates are expected to conduct these work on site with the desktops that are provided.
• Understanding the immune cell biology behind the chosen targets: 20% Reading and discussing the literature regarding the chosen cancer and immune targets and how they are relevant in cancer immunotherapy context.
• Presenting and participating in group meetings in the lab: 10% In a weekly group meeting, the candidate is expected to participate by asking questions and presenting their work to the lab.
• Maintaining and writing protocols for computational pipelines: 10% For each computational work they do (RF diffusion, MPNN), they are required to document the workflow/pipelines so that other students/members in the lab can understand and use it for future design work.

Required Qualifications

To be considered for this opportunity your application must demonstrate you meet both the minimum qualifications and additional qualifications listed below. Equivalent education and/or experience may substitute for minimum qualifications except when there are legal requirements, such as a license, certification, and/or registration.

Minimum Qualifications

• Bachelor's Degree in Biology, Computer Science, or related disciplines and less than one year of relevant experience.

Applicants who do not meet these qualifications WILL NOT be forwarded to the Hiring Manager.

Additional Qualifications

• Experience with Python, protein design, and a background in cell biology, immunology

Preferred Qualifications

• Knowledge of Mammalian cell culture, molecular biology, and flow cytometry.

Compensation, Benefits And Position Details

Pay Range Minimum:

$56,400.00 annual

Pay Range Maximum

$70,800.00 annual

Benefits

Other Compensation: For information about benefits for this position, visit https://www.washington.edu/jobs/benefits-for-uw-staff/

Shift

First Shift (United States of America)

Temporary or Regular?

This is a regular position

FTE (Full-Time Equivalent)

100.00%

Union/Bargaining Unit

UAW Research

About The UW

Working at the University of Washington provides a unique opportunity to change lives - on our campuses, in our state and around the world.

UW employees bring their boundless energy, creative problem-solving skills and dedication to building stronger minds and a healthier world. In return, they enjoy outstanding benefits, opportunities for professional growth and the chance to work in an environment known for its diversity, intellectual excitement, artistic pursuits and natural beauty.

Our Commitment

The University of Washington is committed to fostering an inclusive, respectful and welcoming community for all. As an equal opportunity employer, the University considers applicants for employment without regard to race, color, creed, religion, national origin, citizenship, sex, pregnancy, age, marital status, sexual orientation, gender identity or expression, genetic information, disability, or veteran status consistent with UW Executive Order No. 81.

To request disability accommodation in the application process, contact the Disability Services Office at 206-543-6450 or [e-mail].

Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.