Research Scientist, Biologics Analytics

Vertex Pharmaceuticals Inc (US); United States; On-site; USD 104,000 - 156,000; Full time

Job summary

Vertex is seeking a Research Scientist in Boston, MA to join a collaborative Biologics discovery team. The role focuses on LC-MS based analytical method development and characterization of antibodies, antibody-like scaffolds, bioconjugates, and lipid nanoparticles.

The ideal candidate will work independently, take initiative, and contribute to cross-functional efforts across therapeutic areas, with a strong emphasis on technical excellence and data-driven decision making in a fast-paced setting.

Qualifications

• Ph.D. (or equivalent) in biochemistry or related field with 0–3 years of post‑doctoral experience.
• Masters degree (or equivalent) in biochemistry or related field with 8+ years of experience.

Responsibilities

• Collaborate across therapeutic areas to characterize products supporting program advancement.
• Develop, execute and optimize LC and MS-based methods for proteins, antibodies, and lipid nanoparticles.
• Serve as subject matter expert for LC-MS analysis of proteins and lipid nanoparticles.
• Contribute to developability and manufacturability assessments for product advancement.
• Transfer analytical methods and provide technical support.
• Participate in group and cross-disciplinary project team meetings.

Job description

Job Description Job Description Vertex is seeking a talented Research Scientist to join a collaborative research team focused on Biologics discovery and optimization in Boston, MA. The group’s mission is to deliver next generation biologics and genetic therapies impacting several therapeutic areas. We are looking for a candidate with a strong desire to deliver innovative new medicines to patients in need. In this lab-based role, the ideal candidate is strongly experienced in LC-MS based analytical method development and characterization of biologics including antibodies and antibody-like scaffolds, bioconjugates, and lipid nanoparticles. The candidate should be independent, accustomed to taking initiative, and bring enthusiasm and intellectual curiosity to Vertex’s fast-paced research environment.

Key Responsibilities

• Work collaboratively amongst several therapeutic areas and modalities to provide detailed product characterization to support program advancement
• Develop, execute and optimize LC and MS-based methods for the characterization of proteins, antibodies, antibody-like scaffolds, bioconjugates, and lipid nanoparticles
• Serve as the subject matter expert for LC-MS based analysis of protein and lipid nanoparticles
• Collaborate towards developability/manufacturability assessment in support of product advancement
• Transfer of analytical methods and technical support
• Active participation in group and cross-disciplinary project team meetings

Knowledge and Skills

• Proficient in protein and lipid nanoparticle characterization by liquid chromatography and mass spectrometry
• Familiarity with instrument integration and scheduling tools
• Strong understanding of biologics and lipid nanoparticle manufacturing and critical quality attributes
• Track record of productivity
• Ability to work effectively with cross-functional teams and prioritize multiple programs
• Strong ownership, scientific curiosity, attention to detail, and commitment to technical excellence

Education and Experience

• Ph.D. (or equivalent degree) in biochemistry or related disciplines and 0-3 years of relevant post-doctoral employment experience
• Masters Degree (or equivalent degree) in biochemistry or related disciplines and 8+ years of relevant employment experience

At Vertex we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range

$104,200 - $156,200

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation

On‑Site Designated Flex Eligibility Status: In this On‑Site designated role, you will work five days per week on‑site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.