Research Scientist, Biologics Analytics

Vertex Pharmaceuticals Incorporated; Boston (MA); On-site; USD 104,000 - 156,000; Full time

Job summary

Vertex Pharmaceuticals Incorporated in Boston, MA seeks a talented Research Scientist to advance Biologics discovery. The role emphasizes LC‑MS based method development and characterization of antibodies, antibody‑like scaffolds, bioconjugates, and lipid nanoparticles in a lab‑driven, collaborative setting.

The successful candidate will work with cross‑functional teams, transfer methods, and contribute to developability assessments, with on‑site responsibilities in a fast‑paced research

Qualifications

• Ph.D. (or equivalent) in biochemistry or related discipline, 0-3 post‑doc experience, or
• Masters degree with 8+ years relevant employment in biochemistry or related fields.

Responsibilities

• Work collaboratively across therapeutic areas to provide detailed product characterization.
• Develop, execute and optimize LC and MS‑based methods for proteins, antibodies, and lipid nanoparticles.
• Serve as the subject matter expert for LC‑MS analysis of proteins and lipid nanoparticles.
• Contribute to developability and manufacturability assessments to support product advancement.
• Transfer analytical methods and provide technical support.
• Participate in group and cross-disciplinary project team meetings.

Skills

LC-MS methods

Biologics characterization

Protein & lipid NP analysis

Cross-functional collaboration

Independent initiative

Education

Ph.D. in biochemistry or related

Masters with 8+ years experience

Tools

Instrument scheduling tools

Job description

Job Description

Job Description

Vertex is seeking a talented Research Scientist to join a collaborative research team focused on Biologics discovery and optimization in Boston, MA. The group's mission is to deliver next generation biologics and genetic therapies impacting several therapeutic areas. We are looking for a candidate with a strong desire to deliver innovative new medicines to patients in need. In this lab-based role, the ideal candidate is strongly experienced in LC-MS based analytical method development and characterization of biologics including antibodies and antibody‑like scaffolds, bioconjugates, and lipid nanoparticles. The candidate should be independent, accustomed to taking initiative, and bring enthusiasm and intellectual curiosity to Vertex's fast‑paced research environment.

Key Responsibilities:

• Work collaboratively amongst several therapeutic areas and modalities to provide detailed product characterization to support program advancement

• Develop, execute and optimize LC and MS‑based methods for the characterization of proteins, antibodies, antibody‑like scaffolds, bioconjugates, and lipid nanoparticles

• Serve as the subject matter expert for LC‑MS based analysis of protein and lipid nanoparticles

• Collaborate towards developability/manufacturability assessment in support of product advancement

• Transfer of analytical methods and technical support

• Active participation in group and cross‑disciplinary project team meetings

Knowledge and Skills:

• Proficient in protein and lipid nanoparticle characterization by liquid chromatography and mass spectrometry

• Familiarity with instrument integration and scheduling tools

• Strong understanding of biologics and lipid nanoparticle manufacturing and critical quality attributes

• Track record of productivity

• Ability to work effectively with cross‑functional teams and prioritize multiple programs

• Strong ownership, scientific curiosity, attention to detail, and commitment to technical excellence

Education and Experience:

• Ph.D. (or equivalent degree) in biochemistry or related disciplines and 0-3 years of relevant post‑doctoral employment experience, or
• Masters Degree (or equivalent degree) in biochemistry or related disciplines and 8+ years of relevant employment experience

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision‑making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$104,200 - $156,200

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job‑related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market‑leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week‑long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

On‑Site Designated

Flex Eligibility Status:

In this On‑Site designated role, you will work five days per week on‑site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI‑Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]