Research Lab Tech

Brigham and Women's Hospital; Boston (MA); On-site; USD 29,000 - 40,000; Full time

Job summary

Brigham and Women's Hospital seeks a Technical Research Assistant I to support cardiovascular research using human ESC/iPSC and zebrafish models. The role involves molecular biology work, cell culture, and collaboration to advance disease biomarker discovery.

The candidate will record data meticulously, adapt to protocols, and assist with new techniques while contributing to a team in a dynamic lab environment.

Qualifications

• BA/BS in biology, chemistry, or closely related field.
• 0-1 years experience.
• Prior laboratory research experience preferred.

Responsibilities

• Perform a variety of lab experiments under supervision using PCR, microdissection, western blotting, and RT-qPCR.
• Help maintain zebrafish colonies and assist with cell/tissue culture preparation.
• Prepare reagents and instruments; document procedures in an electronic notebook.
• Collaborate with teammates to meet project goals in a fast-paced wet lab.

Skills

Molecular biology techniques

PCR

Cell culture

Zebrafish handling

Immunofluorescence

Education

BA/BS in biology, chemistry, or closely related field

Job description

Site: The Brigham and Women's Hospital, Inc.

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries.

Job Summary

A research lab within Brigham and Women's Cardiovascular Medicine division is looking for a highly motivated technical research assistant I. The lab uses both in vitro (human ESC/iPSC) and in vivo (zebrafish) techniques to model various cardiovascular disorders, including atrial fibrillation, hypertrophic cardiomyopathy, atherosclerosis, and arteriovenous malformations. By integrating transcriptional, (epi)genetic, metabolic, and phenotypic profiling at whole organism, issue, and single cell-level, the lab aims to understand the earliest molecular events characterizing disease onset, follow-up their dynamic changes over time, and to identify disease biomarkers. The lab also uses these zebrafish models to expedite drug discovery in cardiovascular medicine.

Qualifications

A research lab within Brigham and Women's Cardiovascular Medicine division is looking for a highly motivated technical research assistant I. The lab uses both in vitro (human ESC/iPSC) and in vivo (zebrafish) techniques to model various cardiovascular disorders, including atrial fibrillation, hypertrophic cardiomyopathy, atherosclerosis, and arteriovenous malformations. By integrating transcriptional, (epi)genetic, metabolic, and phenotypic profiling at whole organism, issue, and single cell-level, the lab aims to understand the earliest molecular events characterizing disease onset, follow-up their dynamic changes over time, and to identify disease biomarkers. The lab also uses these zebrafish models to expedite drug discovery in cardiovascular medicine.

PRINCIPAL DUTIES AND RESPONSIBILITIES

• Perform a variety of laboratory experiments under general supervision. These will include molecular and cellular techniques such as PCR, microdissection, western blotting, immunofluorescence microscopy, DNA purification, and quantitative RT-PCR.
• Help to maintain zebrafish colonies.
• Preparation and maintenance of cell and tissue cultures .
• Preparation of laboratory reagents, chemicals, instruments, and equipment.
• Chemical informatics.
• Collaborate with a team of research assistants and post docs to meet project goals in a fast-paced and dynamic wet lab setting.
• Help to establish new and modify existing research techniques.
• Help to coordinate with core facilities and collaborating labs.
• Perform time-lapse microscopy and automated image processing.
• Meticulously record procedures and results in an electronic lab notebook; follow the required safe practices and comply with institutional policies and procedures.
• Discusses progress of work regularly with supervisors.
• May be asked to work some nights and weekends when needed (overtime will apply).
• All other duties, as assigned

QUALIFICATIONS

Required:

• BA/BS in biology, chemistry, or closely related field
• 0-1 years experience

Preferred:

• Prior laboratory research experience.
• Prior experience working with zebrafish.

ADDITIONAL SKILLS/ABILITIES/COMPETENCIES REQUIRED

• Ability to perform a variety of laboratory experiments related to molecular and cellular biology.
• Exceptional ability to participate in team-based, high-throughput laboratory activities.
• Adaptability to changing experimental protocols and willingness to participate in setting up new protocols.
• Strong organizational skills, detail oriented.
• Ability to maintain an accurate and complete electronic lab notebook and electronic logs of stored samples.
• Knowledge of sterile techniques including ability to use pipettes, test tubes, culture dishes and flasks in a cell culture hood.
• Excellent analytical and communication skills.
• Interest in and willingness to accept new responsibilities.
• Ability to lift 20lbs.
• High personal standards for quality, accuracy, and completeness of experimental work

SUPERVISORY RESPONSIBILITIES

None

Additional Job Details (if applicable)

Remote Type

Onsite

Work Location

221 Longwood Avenue

Scheduled Weekly Hours

40

Employee Type

Regular

Work Shift

Day (United States of America)

Pay Range

$21.00 - $29.01/Hourly

Grade

5At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth.

EEO Statement

2200 The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.