Research Fellow-LS-Dr Kun Ling-BMB

Mayo Career Site US; Rochester (MN); On-site; USD 60,000 - 80,000; Full time

Job summary

The Mayo Clinic Translational PKD Center invites applications for a Research Fellow in Life Sciences (LS). The successful candidate will contribute to a project on polycystic kidney disease pathogenesis, using cultured cells, organoids, and mouse models to study primary cilia regulation of cyst formation across development and aging.

Candidates should be highly curious about molecular mechanisms of human diseases and motivated to pursue explorative mechanistic research.

Qualifications

• Knowledge of either clinical-based research or laboratory-based research.
• Experience with molecular cloning and cell-based assays.
• Familiarity with mouse models and MRI imaging.

Skills

Molecular cloning

Mutagenesis

Cell culture and transfection

Immunoblotting

Immunofluorescence microscopy

Proteomics

MRI imaging analysis

Education

Postdoctoral training

Job description

This position opens for a project focused on comprehending the pathogenesis of polycystic kidney disease, the #1 monogenic human disease leading to kidney failure and death. We integrate cultured cell lines, organoids, and animal models to understand how primary cilia regulate the formation of kidney cysts during development and aging. We welcome individuals who are highly curious to molecular mechanisms underlying human diseases and highly motivated and committed to explorative mechanistic research. Common molecular and cellular techniques are required, including molecular cloning, mutagenesis, cell culture and transfection, and immunoblotting.

Experience on recombinant protein expression and pull-down assays would be beneficial. Candidates familiar with various microscope imaging techniques especially immunofluorescence microscopy are highly encouraged to apply. The project also involves proteomics studies, as well as investigating disease phenotype in established mouse models using MRI imaging and histological analyses.

This lab is affiliated with the Mayo Clinic Translational PKD Center and closely collaborates with its world-renown PKD researchers and physicians. Succeeding candidate will have full access to research tools and the state-of-the-art technical services available at the PKD Center, including
patient samples and disease models that can be used for pre-clinical studies if promising drug targets are defined. While we greatly appreciate the independent problem-solving ability that is critical for research, we do recognize the uniqueness of each lab member and encourage teamwork and collaboration, devoting to cultivate a supportive environment to promote personal growth.

A Research Fellow position in Life Sciences (LS) will require knowledge of either clinical-based research or laboratory-based research often obtained from a postdoctoral program.

A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic.