Research Fellow

Mass General Physicians Organization; Boston (MA); On-site; USD 65,000 - 90,000; Full time

Job summary

Massachusetts General Brigham Cancer Center seeks a postdoctoral fellow to study how mutations in IDH alter glioma biology and how this knowledge can guide therapy. The lab uses a mix of CRISPR screening, gene induction/knockdowns, protein biochemistry, and mouse models in collaboration with Harvard programs.

Candidates should have a MD or PhD with strong molecular and cellular biology training and a track record in translational cancer research.

Qualifications

• Postdoctoral candidate with MD or PhD and strong background in molecular and cellular biology.
• Experience with cancer biology or translational cancer research is highly valued.
• Familiarity with in vitro and in vivo experimental techniques is required.

Responsibilities

• Investigate how IDH mutations affect glioma biology and treatment responses.
• Perform in vitro and in vivo experiments including CRISPR screening, gene knockdowns, and mouse modeling.
• Collaborate with multiple research programs and translational partners.

Skills

CRISPR screening

Gene induction

Knockdowns

Protein biochemistry

Transgenic mouse modeling

Flow cytometry

Bioinformatics

Computational biology

Molecular biology

Cellular biology

Education

MD or PhD

Tools

CRISPR

Flow Cytometry

Bioinformatics software

Job description

Site: Massachusetts General Physicians Organization, Inc.

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

Postdoctoral position is available for September 1, 2025 (or later) at the Massachusetts General Brigham Cancer Center for an outstanding candidate interested in cancer biology or translational cancer research. Our laboratory is interested in how mutations in isocitrate dehydrogenase (IDH) alter the biology of glioma brain tumors and how this information can be leveraged to improve treatments for this disease. Our interests lie in basic questions of how mutant IDH affects gliomagenesis and therapeutic stress response, as well as translational questions including how mutant IDH inhibitors may be best employed for this disease.

Our work encompasses a wide range of in vitro and in vivo experimental techniques including CRISPR screening, gene induction and knockdowns, protein biochemistry, transgenic mouse modeling, flow cytometry, and bioinformatic interrogation of clinical samples. MGH is a highly collaborative environment, and our laboratory is within both the Department of Radiation Oncology and the Krantz Family Center for Cancer Research. We are involved in collaborations with multiple other research programs within the scientific community at Harvard and at outside institutions, including programs in functional genomic screening, metabolism, and epigenetics. Previous experience in DNA damage biology, mouse models, and/or computational biology, is especially valued. Highly motivated candidates with an MD or PhD and a strong background in molecular and cellular biology.

Remote Type

Onsite

Work Location

300 First Avenue

Scheduled Weekly Hours

40

Employee Type

Regular

Work Shift

Day (United States of America)

EEO Statement

Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

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At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.