Postdoctoral Research Fellow Venkatesh Lab

Brigham and Women's Hospital; Boston (MA); On-site; USD 74,000 - 81,000; Full time

Job summary

Brigham and Women's Hospital (The Brigham) seeks a Postdoctoral Research Fellow to investigate neuron-cancer interactions at the PNS-tumor interface. The role focuses on electrical underpinnings of cancer progression using electrophysiology, optogenetics, and advanced imaging.

The successful candidate will contribute to groundbreaking research at the intersection of neuroscience and cancer biology, with opportunities for mentoring and publication in high-impact journals.

Qualifications

• Ph.D. in Neuroscience, Cancer Biology, Molecular/Cellular Biology, Bioengineering, or a related field.
• Strong publication record demonstrating expertise in neuroscience techniques and/or cancer biology.
• Ability to work independently and as part of a collaborative, fast-paced research team.
• Excellent written and verbal communication skills in English.

Responsibilities

• Lead and execute independent and collaborative research projects focused on neuron-cancer interactions, particularly within the PNS-tumor interface.
• Design and perform experiments to investigate electrical components of cancer pathophysiology, including neural modulation of tumor growth and malignant transformation.
• Utilize state-of-the-art neuroscience techniques (electrophysiology, optogenetics, chemogenetics, calcium imaging, in vivo neural recordings, behavioral assays) to dissect neural circuitry involved in cancer progression.
• Collaborate with a multidisciplinary team of neuroscientists and cancer biologists at all stages of training.
• Present research findings at lab meetings, seminars, and conferences; prepare manuscripts and contribute to grant proposals.

Skills

Electrophysiology

Patch-clamp

In vivo recordings

Optogenetics

Chemogenetics

Two-photon imaging

Confocal microscopy

Light-sheet microscopy

In vivo murine models

CRISPR

Data analysis

MATLAB

Python

R

FIJI/ImageJ

Education

Ph.D. in Neuroscience

Tools

MATLAB

Python

R

FIJI/ImageJ

Job description

Site: The Brigham and Women's Hospital, Inc.

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

The Venkatesh Lab at Brigham and Women's Hospital (BWH) and Harvard Medical School is a pioneering research group at the forefront of cancer neuroscience, exploring the intersection of cancer biology and neuroscience.

Our work focuses on uncovering the electrical and molecular mechanisms driving neuron-cancer communication. By leveraging state-of-the-art technologies to map neural circuitry and modulate neural activity, we aim to bridge the gap between cancer biology and systems neuroscience, offering new therapeutic possibilities.

Our research characterizes and therapeutically targets neural pathways in both the PNS and CNS, with the goal of developing innovative treatments by exploiting tumor microenvironment dependencies at the neuron-tumor interface. This interdisciplinary approach combines cutting-edge neuroscience techniques with cancer biology to redefine our understanding of malignancy and its systemic connectivity with the brain and body.

Position Overview

We are seeking a highly motivated and creative Postdoctoral Research Fellow to join our team. The ideal candidate will have a strong background in neuroscience techniques and a passion for exploring the electrical underpinnings of cancer progression. This role offers a unique opportunity to contribute to groundbreaking research at the intersection of two constantly evolving fields, with direct implications for the development of novel cancer therapies.

Key Responsibilities

Research & Experimental Design

• -Lead and execute independent and collaborative research projects focused on neuron-cancer interactions, particularly within the PNS-tumor interface.
• -Design and perform experiments to investigate the electrical components of cancer pathophysiology, including neural modulation of tumor growth and malignant transformation.
• -Utilize state-of-the-art neuroscience techniques (e.g., electrophysiology, optogenetics, chemogenetics, calcium imaging, in vivo neural recordings, and behavioral assays) to dissect neural circuitry involved in cancer progression. -Develop and apply molecular and cellular biology techniques (e.g., CRISPR, single-cell RNA sequencing, spatial transcriptomics, and immunofluorescence) to characterize neural and tumor cell interactions.
• -Map systemic brain-body connectivity and its role in cancer biology using advanced imaging (e.g., two-photon microscopy, light-sheet microscopy) and tracing methods.

Technical Expertise

• - Experience with rodent models (e.g., mouse handling, surgical procedures, stereotaxic injections) is required.
• - Experience with neural modulation techniques such as Optogenetics, chemogenetics (DREADDs), or pharmacological manipulation of neural circuits.
• - Skilled in advanced imaging including Confocal microscopy, two-photon imaging, light-sheet microscopy, or super-resolution imaging. - PCR, qPCR, Western blotting, immunofluorescence, FACS, CRISPR-Cas9, viral vector design, and in vitro cell culture (primary neurons, iPSCs, or cancer cell lines).
• - Proficiency in data analysis and visualization using tools such as MATLAB, Python, R, or FIJI/ImageJ. Experience with neural data analysis (e.g., Spike2, NeuroExplorer, or custom scripts) is a plus.
• - Familiarity with electrophysiology, ideally Patch-clamp recording is a plus. Collaboration & Communication -Collaborate with a multidisciplinary team of neuroscientists and cancer biologists at all stages of training.

Collaboration & Communication

• -Collaborate with a multidisciplinary team of neuroscientists and cancer biologists at all stages of training.
• -Present research findings at lab meetings, departmental seminars, and national/international conferences.
• -Prepare manuscripts for publication in high-impact journals and contribute to grant proposals.
• -Mentor graduate students, undergraduate researchers, and technical staff as needed.
• -Maintain accurate and detailed laboratory records and ensure compliance with institutional, ethical, and regulatory standards (e.g., IACUC, biosafety).

Qualifications & Requirements

Ph.D. in Neuroscience, Cancer Biology, Molecular/Cellular Biology, Bioengineering, or a related field.

Strong publication record demonstrating expertise in neuroscience techniques and/or cancer biology.

Ability to work independently and as part of a collaborative, fast-paced research team.

Excellent written and verbal communication skills in English.

Hands-on experience with at least 3 of the following techniques:

• -Electrophysiology (patch-clamp, in vivo recordings) -Optogenetics/chemogenetics
• -Advanced microscopy (two-photon, confocal, light-sheet) -In vivo murine models (rodent survival surgery, )

Preferred Qualifications

• -Experience in cancer neuroscience, neuro-oncology, or tumor microenvironment research.
• -Familiarity with single-cell omics (scRNA-seq, spatial transcriptomics) or bioinformatics analysis.
• -Experience with in vivo imaging of neural activity (e.g., GCaMP, voltage indicators).
• -Knowledge of neuroimmunology, neuroinflammation, or glia-neuron interactions in the context of disease. -Prior work with patient-derived samples or co-culture systems.

Additional Job Details (if applicable)

The salary for this position ranges from $73,544 to $81,199.

Remote Type

Onsite

Work Location

60 Fenwood Road

EEO Statement

2200 The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

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