Research Associate, Supervisor Synthesis Production

AtlasBase; South San Francisco (CA); On-site; USD 85,000 - 125,000; Full time

Job summary

AtlasBase is a fast-growing company pioneering molecular computing solutions. We seek a Research Associate, Supervisor Synthesis Production to lead on-chip DNA synthesis operations, develop SOPs, and manage a small production team.

You will collaborate with scientists and engineers to optimize workflows, analyze QC data, and drive production efficiency while ensuring compliance with SOPs and procedures.

Qualifications

• Bachelor's degree in Biomedical Engineering, Bioengineering, Chemical Engineering, Chemistry, Molecular Biology or other relevant field; 5+ years work experience desirable.
• Experience with custom instrumentation within a workflow; comfortable learning to operate new hardware.
• Experience with automated liquid handlers.
• Experience in solid-phase oligonucleotide (DNA) synthesis (phosphoramidite and/or enzymatic).
• Experience with DNA characterization (Qubit, Nanodrop, Bioanalyzer, CE), PCR, qPCR, LCMS, NGS, DNA hybridization; preferred.

Responsibilities

• Directly support AtlasBase CMOS chip-based DNA synthesis including phosphoramidite and enzymatic workflows.
• Perform on-chip DNA synthesis runs for customers, prep reagents, handle chips, extract DNA, and perform PCR.
• Lead operation of hardware and manage limited-scale production; train RAs and Operators.
• Develop and analyze QC data to ensure samples meet quality before shipment.
• Develop and implement SOPs for production; train team to execute SOPs and optimize turnaround time.

Skills

Automated liquid handling

DNA synthesis

PCR/qPCR

Instrument characterization

Data QC analysis

Team leadership

Education

Bachelor's degree in Biomedical Engineering, Bioengineering, Chemical Engineering, Chemistry, Molecular Biology or related field

Tools

Automated liquid handlers

Qubit

Nanodrop

Bioanalyzer

LCMS

NGS

Job description

Essential Duties and Responsibilities

• Directly support the of Atlas's CMOS chip-based DNA synthesis, including both Phosphoramidite and Enzymatic workflows as required to support product and customer development needs. This will entail working with scientists, engineers, and business development staff on a daily basis.
• Perform regular on-chip DNA synthesis runs for customers, encompassing reagent preparation, chip handling, extraction of DNA, and post extraction PCR, Aliquoting and encapsulation
• Responsible for leading operation of all hardware and managing limited scale production, growing team as business demands. Engineering and Biochemistry will provide needed training and support to assure ongoing success.
• Develop and help analyze QC data, utilize data to ensure that completed samples are all of adequate quality before shipment.
• Develop and implement SOPs for production process. Train and manager RAs and Operators to execute the SOPs effectively. Develop processes to reduce turnaround time and optimize production/

Qualifications

• Bachelor's degree in Biomedical Engineering, Bioengineering, Chemical Engineering, Chemistry, Molecular Biology or other relevant field. 5 plus years work experience in an industry setting is desirable.
• Prior experience with custom instrumentation within a workflow: running experiments to characterize either the instrument, chip, or other modules involved in the process. Comfortable in learning to operate new hardware.
• Experience in using a range of automated liquid handlers
• Experience in research or production of solid phase oligonucleotide (DNA) synthesis (phosphoramidite and/or enzymatic)
• Experience with laboratory techniques including DNA characterization (Qubit, Nanodrop, Bioanalyzer, CE), PCR, qPCR, LCMS, NGS, DNA hybridization assay experience -preferred
• Knowledge of silicon processing techniques or electrochemistry - a plus
• Understanding of micro-scale processes, physics, chemistry, surface chemistry development - a plusd
• Self-learner, self-starter, with the ability to grasp concepts and techniques on the go. Desire to wear multiple hats within a small unit and develop a well-rounded multi-disciplinary profile
• Experience in effectively managing and training small groups of research associates and operators to develop and maintain production efficiency while ensuring compliance with SOPs and need procedures.

About AtlasBase

AtlasBase is a fast-growing pioneer in Molecular Computing, bridging the gap between traditional IT and biotechnology. We are redefining global IT infrastructure by driving breakthroughs in both Molecular Compute and Molecular Data Storage. By commercializing synthetic DNA-based technologies at IT scale, AtlasBase delivers ultra-high-density, low-maintenance, and carbon-conscious solutions built for the explosive growth and value of the world's data. Leveraging nature's most durable medium, we provide a virtually permanent foundation that transforms how the world processes and secures its most critical information.

Originally spun out of Twist Bioscience, our team is an elite fusion of scientists, engineers, and operators dedicated to solving some of the most complex infrastructure challenges on Earth. While our work is grounded in deep science, our success depends on world-class talent across every discipline. We are seeking a Research Associate, Supervisor Synthesis Production who is ready to bring their expertise to a high-impact environment and help us build a brand-new category of technology.