Research Associate / Senior Research Associate, Genomic Core

Xaira Therapeutics; South San Francisco (CA); Vor Ort; USD 90.000 - 115.000; Vollzeit

Zusammenfassung

Xaira Therapeutics, Inc. is seeking a detail-oriented Research Associate / Senior Research Associate to join the Genomic Core, focusing onIllumina-based sequencing, library prep, and single-cell workflows.

You will collaborate with molecular biologists, computational scientists, and platform teams to generate high-quality data and optimize workflows. The role offers core sequencing responsibilities, data QC, and documentation in a fast-paced biotech setting, with opportunities to contribute to

Qualifikationen

• BS/MS in molecular biology or related field with 2+ years in NGS workflows.
• Proficient in Illumina library prep for DNA and RNA.
• Hands-on Illumina sequencer operation and troubleshooting.
• Familiar with single-cell workflows (10x Genomics) preferred.
• Experience with QC methods for nucleic acids and libraries.
• Excellent documentation in a fast-paced environment.

Aufgaben

• Prepare high-quality sequencing libraries for Illumina platforms.
• Operate and maintain Illumina sequencers and monitor runs.
• Support single-cell workflows (10x Genomics GEM-X and Flex).
• Perform QC of input material and libraries and assess data quality.
• Collaborate with internal teams to support NGS needs.
• Develop and optimize NGS protocols and scalable pipelines.
• Maintain ELN records for reproducibility and compliance.

Kenntnisse

NGS workflows

Illumina library prep

Single-cell workflows

Quality control of nucleic acids

Documentation & reproducibility

Ausbildung

BS/MS in Molecular Biology/Genomics/Biotechnology

Tools

10x Genomics GEM-X

10x Genomics Flex

Jobbeschreibung

Research Associate / Senior Research Associate, Genomic Core

About Xaira Therapeutics

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

About the Role

Xaira is seeking a highly motivated and detail-oriented Research Associate / Senior Research Associate to join our Genomic Core team with a focus on next-generation sequencing (NGS). The ideal candidate will have hands-on experience with Illumina-based sequencing technologies, including library preparation, single-cell workflows, and sequencer operation. This position offers the opportunity to contribute to a wide range of projects across therapeutic areas, supporting cutting-edge genomics research and technology development.

You will work closely with molecular biologists, computational scientists, and platform teams to generate high-quality sequencing data, implement new workflows, and ensure best practices in data generation and quality control.

Key Responsibilities

• Prepare high-quality sequencing libraries for Illumina platforms using a range of methods (e.g., TruSeq, Nextera, Amplicon, etc.).
• Operate and maintain Illumina sequencers (e.g., MiSeq, NextSeq, NovaSeq), including run setup, monitoring, troubleshooting, and basic maintenance.
• Support and execute single-cell workflows, including 10x Genomics GEM-X and 10x Flex assays.
• Perform QC of input material and libraries (e.g., Bioanalyzer, TapeStation, Qubit, qPCR) and assess data quality post-sequencing.
• Collaborate with internal teams to support project-specific NGS needs.
• Troubleshoot experimental issues independently and suggest improvements to protocols and workflows.
• Develop and optimize NGS protocols and contribute to the scaling of automated or high-throughput sequencing pipelines.
• Contribute to the development of scalable, high-throughput cloning and viral production pipelines.
• Maintain detailed electronic lab notebook (ELN) records and ensure rigorous documentation for reproducibility and compliance.
• Participate in group meetings and communicate experimental progress, challenges, and insights to broader teams.
• Running analysis pipelines (e.g., bcl2fastq, CellRanger, etc).

Qualifications

• B.S./M.S. in Molecular Biology, Genomics, Biotechnology, or a related field with 2+ years of laboratory experience, including direct experience in NGS workflows.
• Proficient in Illumina sequencing library preparation methods for DNA and RNA, with a strong understanding of underlying biochemistry and assay design.
• Hands-on experience with Illumina sequencer operation and troubleshooting.
• Familiarity with single-cell workflows (e.g., 10x Genomics GEM-X) and/or 10x Genomics Flex assays is strongly preferred.
• Experience with quality control methods for nucleic acids and libraries (e.g., fragment analysis, fluorometric quantification, library quantification).
• Strong organizational skills and meticulous attention to detail in both benchwork and data documentation.
• Familiarity in library cloning techniques such as vector design, PCR, assembly methods (e.g. Gibson, Golden Gate), and bacterial transformation is a plus.
• Comfortable working in a fast-paced, collaborative environment, supporting multiple projects and stakeholders.
• Knowledge of high-throughput or automated NGS library prep platforms is a plus.
• Familiarity with cloud-based LIMS or data tracking systems (e.g., Benchling, BaseSpace) is a plus.
• Basic knowledge of NGS data analysis (e.g., demultiplexing, QC metrics interpretation, familiarity with sequencing file formats) is a plus.

Compensation

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $90,000 - $115,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Xaira Therapeutics’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

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An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.