Research Associate II/Senior Research Associate, Oligonucleotide Foundry

Tesseratx; Somerville (MA); On-site; USD 80,000 - 100,000; Full time

Job summary

An innovative biotechnology firm is seeking a Research Associate II/Senior Research Associate to join their Oligonucleotide Foundry team. This role offers a unique opportunity to work on pioneering Gene Writing technology, aimed at curing diseases at their source. The ideal candidate will have a strong background in chemistry or biology, with hands-on experience in downstream processing and lab instrumentation. You will engage in cross-functional research, develop purification strategies, and contribute to the advancement of genetic medicine. Join a creative and collaborative team committed to scientific excellence and make a meaningful impact in the field.

Qualifications

• 2+ years of experience in chemistry or biology for BS holders; 1+ years for MS holders.
• Strong knowledge of oligonucleotide processing and lab instruments.

Responsibilities

• Learn and implement purification strategies for complex oligonucleotides.
• Conduct research into alternate purification strategies.

Skills

Chemistry

Biology

Downstream processing of oligos

Buffer preparation

HPLC

LC-MS

Analytical instruments (Agilent, Waters)

Electronic Lab Notebooks (ELNs)

Education

BS in Chemistry, Biology, or related life sciences

MS in Chemistry, Biology, or related life sciences

Tools

AKTA purifiers

UF

HPLC

LC-MS

Job description

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Your Experience Includes…

• BS with 2+/MS with 1+ years of relevant experience in chemistry, biology, or related life sciences
• Excellent knowledge and thorough understanding of downstream processing of oligos
• Experience in preparing buffers for purification and maintaining lab instruments such as AKTA purifiers, UF, HPLC and LC-MS
• Experience using Agilent and Waters analytical instruments for purity analysis
• Detail and results oriented with experience using ELNs to document experiments and results

You are interested in…

• Learning and implementing purification strategies for complex oligonucleotides
• Conducting research into alternate purification strategies
• Preparing transfer of methods to larger-scale cGMP manufacturing environment
• Performing routine operations for critical technology components
• Participating in cross-functional teams and training to gain familiarity in all stages of oligonucleotide research and manufacturing

About you:

You are a skilled individual who can operate in a fast-paced environment, troubleshoot instruments, and document operations independently and as part of a team. You will have the opportunity to organize and present results within the group and interface with other teams, so strong communication skills are critical. You enjoy overcoming challenges in collaboration with colleagues.

Tessera employees are creative and collaborative problem solvers. They have a strong sense of integrity and unwavering commitment to scientific excellence.

Company Summary:

Tessera Therapeutics is pioneering Gene Writing— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy.

More about Tessera Therapeutics:

Tessera is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate.