Research Associate II/Senior Research Associate, Oligonucleotide Foundry

Tessera Therapeutics; Somerville (MA); On-site; USD 60,000 - 100,000; Full time

Job summary

An innovative biotechnology company is seeking a skilled individual to join their team in a fast-paced environment focused on Gene Writing. This role involves learning and implementing purification strategies for oligonucleotides, conducting research into purification methods, and preparing for large-scale cGMP manufacturing. The successful candidate will have the chance to collaborate with colleagues, troubleshoot lab instruments, and document results effectively. This opportunity offers a unique chance to contribute to groundbreaking advancements in genetic medicine while working alongside creative problem solvers committed to scientific excellence.

Qualifications

• BS with 2+ years or MS with 1+ years in chemistry, biology, or related life sciences.
• Experience in downstream processing and lab instrument maintenance.

Responsibilities

• Learn and implement purification strategies for complex oligonucleotides.
• Participate in cross-functional teams and document operations.

Skills

Downstream processing of oligos

Buffer preparation for purification

Lab instrument maintenance (AKTA, UF, HPLC, LC-MS)

Purity analysis using Agilent and Waters instruments

Documentation using ELNs

Strong communication skills

Education

BS in Chemistry or Biology

MS in Chemistry or Biology

Tools

AKTA purifiers

HPLC

LC-MS

Agilent analytical instruments

Waters analytical instruments

Job description

Somerville, Massachusetts, United States

Qualifications:

1. BS with 2+/MS with 1+ years of relevant experience in chemistry, biology, or related life sciences
2. Excellent knowledge and thorough understanding of downstream processing of oligos
3. Experience in preparing buffers for purification and maintaining lab instruments such as AKTA purifiers, UF, HPLC and LC-MS
4. Experience using Agilent and Waters analytical instruments for purity analysis
5. Detail and results oriented with experience using ELNs to document experiments and results

You are interested in:

1. Learning and implementing purification strategies for complex oligonucleotides
2. Conducting research into alternate purification strategies
3. Preparing transfer of methods to larger-scale cGMP manufacturing environment
4. Performing routine operations for critical technology components
5. Participating in cross-functional teams and training to gain familiarity in all stages of oligonucleotide research and manufacturing

About you:

You are a skilled individual who can operate in a fast-paced environment, troubleshoot instruments, and document operations independently and as part of a team. You will have the opportunity to organize and present results within the group and interface with other teams, so strong communication skills are critical. You enjoy overcoming challenges in collaboration with colleagues.

Tessera employees are creative and collaborative problem solvers. They have a strong sense of integrity and unwavering commitment to scientific excellence.

Company Summary:

Tessera Therapeutics is pioneering Gene Writing— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

More about Tessera Therapeutics:

Tessera is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate.