Research Associate II/Senior Research Associate, Drug Discovery

Jnana Therapeutics; Boston (MA); On-site; USD 65,000 - 85,000; Full time

Job summary

Jnana Therapeutics is seeking a Research Associate II/Senior Research Associate to join their innovative team in Boston. This role involves conducting cell-based assays and developing drug discovery models. Ideal candidates will have a Bachelor's degree in Biology and relevant industry experience. Join a collaborative culture dedicated to advancing therapies for challenging diseases.

Qualifications

• 2+ years of relevant industry experience in a Drug Discovery setting.

Responsibilities

• Perform routine cell culture and develop novel cell lines.
• Screen compounds through biochemical and cellular assays.
• Document and communicate research outcomes.

Skills

Cell Culture

Data Analysis

Communication

Education

Bachelor's degree in Biology

Tools

CRISPR

RT-qPCR

Western Blotting

ELISA

Flow Cytometry

Job description

About UsJnana Therapeutics, a wholly owned subsidiary of Otsuka Pharmaceutical, is a clinical-stage biotechnology company leveraging its next-generation RAPID chemoproteomics platform to discover medicines for highly validated, challenging-to-drug targets to treat diseases with high unmet needs. Jnana is focused on developing first- and best-in-class therapies to treat a wide range of diseases, including rare diseases and immune-mediated diseases. Jnana's lead program, JNT-517, which targets an allosteric site on the phenylalanine transporter SLC6A19, is a potential first-in-class oral approach for the treatment of PKU, a rare genetic metabolic disease. Located in Boston, Jnana brings together scientific leaders in small molecule drug discovery and development, and a highly experienced management team. For more information, please visit www.jnanatx.com and follow us on Twitter/X and LinkedIn.

At Jnana, you'll join a diverse, passionate team dedicated to advancing therapies for challenging diseases. Our collaborative, purpose-driven culture fosters innovation, urgency, and belonging-making Jnana a great place to work!

About the OpportunityJnana Therapeutics is hiring a Research Associate II/Senior Research Associate with a strong scientific drive and passion for innovation in a team-focused environment. This role will conduct cell-based and biochemical assays, develop novel cell models, and investigate compound mechanisms to support pharmacology and drug discovery efforts

Responsibilities

• Perform routine cell culture, as well as develop and characterize novel cell lines and primary cell systems for pharmacology studies and disease modeling applications.
• Screen compounds through various biochemical and cellular assays to support Med Chem design decisions.
• Design, execute, and troubleshoot mechanism of action studies seeking to understand the activity of emerging compounds.
• Perform independent data analysis and interpretation to support outlining of next steps and recommendations on research approach.
• Clearly document and communicate research outcomes to colleagues at team-level and company-level science meetings.

Preferred Qualifications & Past Experience

• Bachelor's degree in Biology or another related field.
• 2+ years of relevant industry experience in a Drug Discovery setting.
• Experience with a broad range of measures including reporter gene assays, HiBit, NanoBRET, MSD/AlphaLISA, construct design, siRNA/shRNA, CRISPR, RNA extractions, RT-qPCR, Western blotting and imaging, ELISA-based assays, Flow cytometry analysis among others.
• Experience with liquid handling/robotics is a plus.
• Hands-on experience in immune cell assays, PBMC isolation, and cell-based in vitro assays.
• Must be a scientifically motivated self-starter, able to work effectively in a fast-paced team environment and have a high level of independence for planning and executing project requirements in a timely manner.