Research Associate II

Spectraforce Technologies; Lexington (MA); On-site; USD 65,000 - 90,000; Full time

Job summary

Spectraforce Technologies in Lexington, MA is seeking a Research Associate to provide technical laboratory research support across multiple projects focused on expedited evaluation and clinical translation of therapies.

The position emphasizes mammalian cell culture, cell-based assays, RNA extraction and RT-qPCR, data analysis, and clear documentation. You will collaborate with the research team to address critical questions and advance drug candidates toward defined goals.

Qualifications

• Master's in Cell and Molecular Biology or Pharmaceutical Sciences (required or preferred).
• 4+ years of relevant drug discovery laboratory experience preferred.
• Experience with cellular and molecular biology essential (mammalian cell culture, cell-based assays, qPCR).

Responsibilities

• siRNA drug candidate screening, hit identification, and lead optimization.
• Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; RNA extraction and RT-qPCR.
• Analyze data and present the results in group meetings.
• Maintain clear experimental records in laboratory notebooks; write SOPs and other technical reports as needed.
• Work closely with research team members to quickly and effectively address critical questions related to the efficacy of our drugs.
• Review literature and provide insights to research directions, while predominantly making hands‑on contributions to the research.

Skills

mammalian cell culture

cell-based assays

quantitative real-time PCR

Education

Master's in Cell and Molecular Biology or Pharmaceutical Sciences

Job description

Job Title: RESEARCH ASSOCIATE

Location: 65 Hayden Ave Lexington, MA 02421

Duration: 1 year

Reporting Expectations: Onsite

Top Skills per Manager

• mammalian cell culture
• cell-based assays
• quantitative real-time PCR

Purpose

To provide technical laboratory research effort in support of multiple projects focused on expedited evaluation and the clinical translation of therapies.

Essential Functions

• siRNA drug candidate screening, hit identification, and lead optimization
• Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; RNA extraction and RT-qPCR
• Analyze data and present the results in group meetings
• Maintain clear experimental records in laboratory notebooks; write SOPs and other technical reports as needed
• Work closely with research team members to quickly and effectively address critical questions related to the efficacy of our drugs
• Review literature and provide insights to research directions, while predominantly making hands‑on contributions to the research

Qualifications

• Master's in Cell and Molecular Biology or Pharmaceutical Sciences
• 4+ years of relevant drug discovery laboratory experience in industrial or academic environment is preferred
• Experience in cellular and molecular biology is essential (e.g., mammalian cell culture, cell-based assays, quantitative real-time PCR)
• Experience with primary human adipocytes and hepatocytes culture is preferred
• Experience with advanced in vitro model systems including organoids and other 3D culture systems is highly preferred
• Experience with RNAi and in vitro screening is preferred
• Candidate must have strong oral and written communication skills, strong work ethics and demonstrated to be an effective contributor to group projects in a team-oriented environment
• The ability to perform and interpret experiments reliably, and to advance projects aggressively towards defined goals is expected