Research Associate I

Spectraforce Technologies, Inc.; Boulder (CO); On-site; USD 60,000 - 90,000; Full time

Job summary

Spectraforce Technologies, Inc. in Boulder, CO is seeking a Research Associate for RNAi Chemical Development.

This 1+ year onsite role supports delivery of oligonucleotide starting materials to innovation and process development teams, enabling ligation-based RNAi manufacturing development and platform expansion. You will execute synthesis, purification, and related laboratory procedures, maintain workflows and equipment, and contribute to efficiency improvements in a fast-paced,

Qualifications

• Education: Bachelor’s or Master’s in chemistry, biochemistry, or related field.
• Experience: 0-3+ years of relevant lab experience.
• Familiar laboratory techniques and SOP adherence.

Responsibilities

• Prepare and deliver oligonucleotide starting materials.
• Execute synthesis, processing, and purification procedures.
• Operate and maintain workflows for reliable material supply.
• Support ligation development through substrate preparation.
• Maintain equipment and document workflows.
• Drive continuous improvement in efficiency and scalability.

Skills

Laboratory techniques

HPLC/LC-MS experience

Oligonucleotide synthesizers

Ion-exchange purification

RNAi/oligonucleotide chemistry

Education

Bachelor's or Master's in chemistry/biochemistry or related field

Tools

Mermade systems

Job description

Title: Research Associate, RNAi Chemical Development

DURATION: 1+ year with the potential to extend (up to 2-year max)

LOCATION: Boulder, CO - ONSITE

SCHEDULE: 8am-5pm (some flexibility)

MUST HAVES

1. Science/engineering degree (AS, BS, BA degree)
2. Excitement for the role and willing personality
3. Team mentality and strong communication skills

PURPOSE

This role supports delivery of high-quality oligonucleotide starting materials to innovation and process development teams, enabling ligation-based RNAi manufacturing development and platform expansion.

The position is responsible for maintaining a reliable supply system to support fast-paced program advancement.

RELATIONSHIPS

Collaborates with RNAi Chemical Development, Innovation, and Scale-Up teams.

Interfaces with API development and oligonucleotide production stakeholders.

Individual contributor within a cross-functional environment.

ESSENTIAL FUNCTIONS

• Support preparation and delivery of oligonucleotide starting materials.
• Execute laboratory procedures related to oligonucleotide synthesis, processing, and purification.
• Operate and maintain workflows ensuring reliable material supply.
• Support ligation development through timely substrate preparation.
• Maintain equipment and document workflows and materials.
• Drive continuous improvement in efficiency and scalability.

QUALIFICATIONS

Education: Bachelor's or Master's in chemistry, biochemistry, or related field.

Experience: 0-3+ years of relevant lab experience.

Technical Skills

• Familiarity with standard laboratory techniques.
• Experience with HPLC or LC-MS is a plus.
• Familiarity with automated oligonucleotide synthesizers (e.g., Mermade systems) is preferred.
• Experience with ion-exchange purification methods for oligonucleotides is preferred.
• Basic understanding of RNAi or oligonucleotide chemistry preferred.