RCI-AZN-33116 Analytical Technology Scientist

Rangam; Santa Monica (CA); Sur place; USD 120 000 - 190 000; Plein temps

Résumé du poste

Rangam in Santa Monica, CA seeks a seasoned Analytical Technology Scientist to evaluate live-cell imaging and analysis platforms for QC applications. You will design and run experiments, compare platforms to current QC methods, and develop protocols for scalable, automated high-throughput QC workflows.

You will work independently in a technically oriented operations setting, partnering with automation, data science, and instrument vendors to meet regulatory expectations.

Qualifications

• PhD in cell biology, molecular biology, immunology, or related field (completed by start date).
• Hands-on cell imaging experience (fluorescence, confocal, imaging flow cytometry).
• Primary cell culture with aseptic technique.
• Independent work style with experimental design and stats understanding.
• Initiative and proactive communication on progress and deadlines.
• Experience with primary T cells a plus.
• GxP or cell therapy exposure preferred.

Responsabilités

• Evaluate new live-cell imaging and analysis platforms for potential QC use.
• Conduct hands-on experiments to address assay gaps.
• Set up, optimize, and troubleshoot in-vitro/ex-vivo experiments.
• Establish proper controls and parameters for assays.
• Work with primary T cells and imaging methods.
• Collaborate with SMEs and cross-functional partners.
• Operate in a BSL-2 laboratory.

Connaissances

Independent work

Experiment design

Critical thinking

Imaging expertise

Data interpretation

Communication skills

Biology knowledge

Formation

PhD in related field

MS + 4+ years hands-on research

Outils

Benchling ELN

GraphPad Prism

JMP

CellProfiler

Fiji/ImageJ

Python

High-content imaging

Flow cytometry

Description du poste

Monday–Friday, day shift, 8:00 am–5:00 pm; cell culture is scheduled to avoid weekend work

100% onsite for the first 3 months - they possible hybird

Prioritize candidates with a PhD degree, rather than MS

• A curious, resourceful scientist who can think critically and work independently.
• Someone who can design experiments, identify appropriate controls, and determine the right parameters without step-by-step direction.
• Hands-on wet-lab experience, including preparing cell dilutions and mixtures.
• Careful handling of delicate primary T-cell cultures.
• Imaging experience, including setting up image acquisition; experience with a specific instrument is not required.
• Ability to optimize experiments, troubleshoot results, and learn new technologies, platforms, and software quickly.
• Clear communication of scientific methods, findings, and reasoning.
• A PhD in T-cell biology, immunology, molecular biology, or cellular biology is preferred.
• Candidates with a master's degree and substantial relevant academic research experience are also encouraged to apply.
• Cell therapy or industry experience is not required; candidates transitioning from academia are welcome.
• Relevant publications in T-cell imaging, T-cell assays, or in-vitro assay optimization are a plus.

What the role entails

• Evaluate new technologies, platforms, and software for potential use in cell therapy quality control.
• Conduct hands-on experiments to investigate technical questions and address assay gaps.
• Set up, optimize, and troubleshoot in-vitro/ex-vivo experiments.
• Establish appropriate experimental controls and parameters.
• Work with primary T-cell cultures and imaging methods.
• Collaborate with subject-matter experts and internal stakeholders.
• Work in a BSL-2 laboratory.

Education

• PhD preferred; MS with 4+ years of hands-on research experience considered

Reports to

• Senior Scientist, within a collaborative department of about 20 scientists

Job summary

Want your experiments to shape how next-generation cell therapies are tested?

• You will evaluate emerging live-cell imaging and cell analysis platforms, benchmark them against current QC methods, and recommend which ones move into automated, high-throughput QC.
• Unlike discovery or academic research, this role sits in technical operations: each study answers a defined business question on a set timeline, and methods must ultimately meet regulatory expectations. You will partner with analytical automation, analytical development, data science, QC and Lab Operations/IT teams, as well as instrument vendors.
• This is not an entry-level role. It suits PhD scientists moving into industry, or experienced MS scientists. You will work independently with minimal supervision, so candidates who can initiate work and deliver on time-sensitive projects are especially encouraged to apply.

Key responsibilities

• Design and run feasibility studies, demos and vendor evaluations of new live-cell imaging and cell analysis platforms, such as high-content imagers, flow cytometers and cell imagers from Yokogawa (e.g., CQ1), Revvity, Agilent, BD, Molecular Devices and Thermo Fisher Scientific.
• Benchmark new platforms against current QC methods on accuracy, precision, sensitivity, robustness, throughput and hands-on time.
• Culture genetically modified primary human T cells and cell lines using aseptic technique; count, assess viability, normalize to target densities and plate into multi-well assays, manually or with semi-automated tools.
• Prepare cell samples and experimental conditions for assays: fluorescent antibody staining and titration for flow and imaging cytometry, serial dilutions of cell densities, and conditions such as heat-killed controls and effector-to-target (E:T) cytotoxicity co-cultures.
• Develop, optimize and troubleshoot imaging-based assays, from sample preparation through image acquisition and analysis.
• Work with automation and data science colleagues to adapt promising methods for integration with lab automation.
• Analyze data with appropriate statistics and communicate findings through reports and presentations.
• Document work in an electronic lab notebook (e.g., Benchling) following good documentation practices.
• Serve as a technical contact for vendors and cross-functional partners.
• Order reagents and consumables, and keep instruments and lab areas in good working order.
• You will own each evaluation end to end, from plan to recommendation:
• Evaluation plans with clear success criteria
• Comparison data and gap analyses
• Desk-based projections of ROI and key assay parameters (e.g., throughput, cost per sample, hands-on time) that compare similar technologies and instruments
• Assessment reports with a clear recommendation: adopt, adapt or do not pursue
• Draft protocols and SOP inputs for platforms that move forward

Required qualifications

• PhD in cell biology, molecular biology, immunology, bioengineering or a related field (completed by start date), or an MS in a related field with 4+ years of hands-on research experience
• Hands-on cell-based imaging experience, such as fluorescence or confocal microscopy, high-content imaging or imaging flow cytometry
• Hands-on primary cell and cell line culture, counting and assay plating with strong aseptic technique
• A track record of working independently with minimal supervision: designing and running experiments end to end, with appropriate controls, replicates and statistics
• Takes initiative rather than waiting for tasks to be assigned, and communicates proactively to discuss progress and deliver results on time-sensitive deadlines

Preferred qualifications

• Working knowledge of fluorescent antibody staining and titration for flow or imaging cytometry, including designing basic 5-color panels
• Experience with primary T cells, cell therapy or GxP environments
• Data and image analysis with tools such as GraphPad Prism, JMP or vendor imaging software, plus scripting (e.g., Python, CellProfiler, Fiji/ImageJ)
• Detail-oriented and organized across several concurrent projects
• Familiarity with method qualification and validation (e.g., ICH Q2(R2), Q14)
• Lab automation or liquid handler experience
• Experience with Benchling or another ELN

Physical requirements and working conditions

• Fully on-site, with about 75% of time in the lab
• BSL-2, GxP-aligned development laboratory (non-GMP) handling human cells; biosafety and bloodborne pathogen training and appropriate PPE (e.g., lab coat, gloves, eye protection) required
• Standing for extended periods at the bench or biosafety cabinet
• Lifting and moving items up to 10 lb, such as media, reagent cases and small equipment

Career Link: https://talentarbor.com/job/details/142718/3/159/analytical-technology-scientist-santa-monica-ca-us