R&D Engineer II — Single-Cell Tech & Diagnostics

Biohub; New York (NY); Hybrid; USD 153,000 - 191,000; Full time

Benefits offered by this job

401(k) match

Paid time off

Relocation support

Family-forming benefits

Job summary

Biohub is advancing single-cell technologies to study human disease and immune interactions. The R&D Engineer II will create devices for high-throughput screening, bridging engineering and biology, with ownership from concept to prototype.

The role requires a strong engineering track record, hands-on lab work, and the ability to document progress while collaborating across teams in a hybrid NYC setting.

Qualifications

• Bachelor's or Master’s Degree in Engineering plus 5+ years of hands-on engineering experience.
• Track record of developing diagnostic or point-of-care medical devices.
• Experience with handling biological samples.
• Proficiency in CAD.
• Experience with 3D printing and rapid prototyping.
• Ability to independently design rigorous experiments, troubleshoot complex workflows, and drive projects to completion.
• Strong documentation habits.
• Collaborative mindset and strong scientific communication skills.

Responsibilities

• Design, build and test prototypes for point-of-care sample processing, iterating based on performance data and optimizing for reproducibility.
• Design mechanisms for controlled timing and sequencing of biochemical processes within a device (e.g., controlled reagent release, passive valving, or equivalent)
• Perform hands-on preparation and handling of biological specimens, and conduct assay validation experiments (e.g., timing precision, reagent activity, sample/cell quality at endpoint)
• Apply domain knowledge across device engineering, cell biology, and materials science to guide hardware design decisions
• Establish test protocols and acceptance criteria to ensure reproducible performance across prototype iterations and production lots
• Participate in discussions with project collaborators
• Carefully document work
• Clearly report on project progress
• Contribute to scientific publications and patent applications

Skills

CAD

3D printing

Experiment design

Documentation

Collaboration

Biology knowledge

Python

Education

Bachelor's or Master’s Degree in Engineering

Tools

CAD software

3D printing equipment

Python

Job description

Biohub is advancing single-cell technologies to study human disease and immune interactions. The R&D Engineer II will create devices for high-throughput screening, bridging engineering and biology, with ownership from concept to prototype.

The role requires a strong engineering track record, hands-on lab work, and the ability to document progress while collaborating across teams in a hybrid NYC setting.