QC Associate II: Data-Driven QC & NGS Analysis

Twist Bioscience; Portland (OR); On-site; USD 65,000 - 90,000; Full time

Job summary

Twist Bioscience in Portland, OR, is seeking a QC Associate II to implement and continuously improve QC methods in the production laboratory, collaborating with the operations team to ensure Twist DNA products meet specifications through quantitative measurements and sequencing.

You will perform QC release for standard product families, troubleshoot assays (NGS, qPCR, fragment analysis, NanoDrop/Qubit), and initiate nonconformances while supporting investigations and root-cause analysis.

Qualifications

• BS/MS in Biochemistry, Chemistry, Molecular Biology or related field.
• 2+ years industrial experience in Operations/QC.

Responsibilities

• Independently perform QC release for standard product families to ensure 100% compliance with customer specifications.
• Execute and troubleshoot routine QC assays (NGS, qPCR, fragment analysis, NanoDrop/Qubit); identify and escalation atypical results.
• Initiate Nonconformances and other Quality Events for OOS, OOT, and atypical results, and follow up on progress and action items.
• Support impact assessments and investigations; contribute to root cause analysis using 5-Why, Fishbone, and DMAIC techniques.
• Review CAPAs and process deviations from a QC perspective.
• Monitor QC data and assist in preparation of product and process quality reports, including trend analysis.
• Author and review product quality documentation (SOPs, test methods, work instructions, labels).
• Maintain QC batch records, calibration records, and inventory under ISO and GDP requirements.
• Identify and support continuous improvement initiatives in the QC laboratory.

Skills

Data-driven decisions

Communication skills

Troubleshooting

Root cause analysis

Quality mindset

Education

BS/MS in Biochemistry, Chemistry, Molecular Biology or related field

Tools

LIMS systems

NanoDrop

Qubit

NGS instrumentation

Job description

Twist Bioscience in Portland, OR, is seeking a QC Associate II to implement and continuously improve QC methods in the production laboratory, collaborating with the operations team to ensure Twist DNA products meet specifications through quantitative measurements and sequencing.

You will perform QC release for standard product families, troubleshoot assays (NGS, qPCR, fragment analysis, NanoDrop/Qubit), and initiate nonconformances while supporting investigations and root-cause analysis.