Proteome Editor Design Lead

Allen Institute; Seattle (WA); On-site; USD 128,000 - 160,000; Full time

Benefits offered by this job

Relocation assistance

Visa sponsorship potential

Job summary

The Allen Institute in Seattle is seeking a Scientist III to lead the Proteome Editor design flywheel within the AI BioDesign initiative. You will guide a team focused on design–test–learn loops for proteome editors, in collaboration with ML colleagues to optimize data and models.

You will drive high‑throughput screening programs, curate datasets, and advance active‑learning strategies while coordinating with other teams to accelerate discovery and publish results in scientific forums.

Qualifications

• PhD in biochemistry, molecular biology, or a related field.
• Minimum 5 years of relevant post‑doctoral experience.
• Experience with functional genomics, massively parallel reporter assays, multiplexed assays of variant effect, saturation mutagenesis, or plasmid library‑based screening.
• Experience architecting cellular library screening workflows (e.g., MPRAs or other high‑throughput cell‑based discovery platforms).
• Proven ability to lead scientific projects and collaborate cross‑functionally, including partnering effectively with computational/ML teammates.

Responsibilities

• Lead the Proteome Editor team to build and run a rapid, repeatable design–test–learn pipeline focused on proteome editor screening.
• Design and oversee library screening and degrader evaluation experiments to generate high‑quality, model‑ready datasets.
• Partner with machine learning colleagues to define next targets, curate data, and implement active‑learning strategies.
• Optimize flywheel performance by improving turnaround time, throughput, cost, and per‑cycle model lift; remove bottlenecks.
• Coordinate with other flywheel leads and stakeholders to align priorities and timelines across the program.
• Mentor and manage a high‑performing team, fostering collaboration and clear communication.
• Present scientific results in talks and progress reports; share externally at conferences and in publications.

Skills

Leadership & team management

Cross-functional collaboration

Experimental design

Cell-based library screening

Functional genomics

ML collaboration

Education

PhD in biochemistry or molecular biology

Job description

The Allen Institute in Seattle is seeking a Scientist III to lead the Proteome Editor design flywheel within the AI BioDesign initiative. You will guide a team focused on design–test–learn loops for proteome editors, in collaboration with ML colleagues to optimize data and models.

You will drive high‑throughput screening programs, curate datasets, and advance active‑learning strategies while coordinating with other teams to accelerate discovery and publish results in scientific forums.