Protein Design Intern - Bioinformatics & Linux HPC

Syngentagroup; Durham (NC); On-site; USD 28,000 - 62,000; Full time

Benefits offered by this job

Emerging Talent Program

Hands-on experience

Professional development

Job summary

Syngenta's Bioinformatics Team in Durham, NC seeks a Protein Design Intern to join a high-performance scientific team. You will apply computational design methods to generate novel protein candidates and minibinders, optimize workflows, and evaluate variants using sequence- and structure-based analyses.

The role is part of the Emerging Talent Program and offers hands-on experience with open-source tools. Responsibilities include designing, ranking, and filtering protein candidates, running tools

Qualifications

• Pursuing MS/PhD in bioinformatics or related field.
• Proficiency in Python and Bash scripting.
• Knowledge of protein structure concepts, including protein domains and interfaces.
• Familiarity with protein structure prediction methods such as Boltz-2 or AlphaFold.
• Experience with Linux/Unix command line.

Responsibilities

• Apply computational protein design methods to generate novel protein candidates and minibinders to selected targets.
• Optimize workflows that integrate protein design, structure prediction, and ranking approaches.
• Evaluate designed protein variants using sequence- and structure-based analyses.
• Test and run computational protein design tools in Linux, HPC, or cloud environments like AWS.
• Develop Python/Bash scripts for data processing and workflow automation.
• Document workflows, write READMEs, and present findings to cross-functional teams.
• Collaborate with scientists to refine design strategy based on biological insights.
• Summarize results in reports and visuals for follow-up testing.

Skills

Python

Bash

Linux

Data analysis

Communication

Education

MS or PhD student in Bioinformatics, Computational Biology, Structural Biology, Biochemistry, Computer Science, or related field

Tools

PyMOL

ProteinMPNN

Boltz-2

AlphaFold

RFdiffusion

Job description

Syngenta's Bioinformatics Team in Durham, NC seeks a Protein Design Intern to join a high-performance scientific team. You will apply computational design methods to generate novel protein candidates and minibinders, optimize workflows, and evaluate variants using sequence- and structure-based analyses.

The role is part of the Emerging Talent Program and offers hands-on experience with open-source tools. Responsibilities include designing, ranking, and filtering protein candidates, running tools