Protein Design Intern

ISU Research Park; Durham, Northern (NC, KY); Hybrid; USD 22,000 - 33,000; Full time

Job summary

Syngenta's Bioinformatics Team invites a Protein Design Intern to Durham, NC, to join a high-performance scientific team. You will develop computational workflows to spot novel proteins, work with structure- and sequence-based search methods, and contribute to a collaborative Emerging Talent program.

You will gain hands-on experience, applying academic knowledge to real challenges, while building professional skills and contributing to cross-functional projects.

Qualifications

• Current MS or PhD student in Bioinformatics, Computational Biology, Structural Biology, or a related field.

Responsibilities

• Apply structural bioinformatics methods to discover novel proteins.
• Develop computational workflows that integrate sequence- and structure-based search algorithms to identify and rank protein candidates.
• Leverage protein structure-based search workflows using tools such as FoldSeek, ESMFold, and Boltz.
• Perform structural analysis and annotation of protein candidates.
• Develop Python/Bash scripts for data processing and visualization.
• Document workflows, create user guides, and present findings to cross-functional teams.
• Collaborate with other scientists to refine research strategies based on biological insights.
• Share results and learnings at team meetings and educate team members on workflows and results.

Skills

Python

R

Linux CLI

Data analysis

Education

MS/PhD student in Bioinformatics/Computational Biology/Structural Biology

Tools

FoldSeek

ESMFold

Boltz

PyMOL

Job description

At Syngenta Seeds Field Crops, we're shaping the future of agriculture and empowering farmers to meet the ever-growing demand for food and fuel. We’re a global Ag Tech powerhouse, headquartered in the United States, with passionate, local experts collaborating with farmers to deliver solutions that create market opportunities.We unite precision breeding, advanced biotechnology trait choice, and digital platforms for unmatched in-field performance.Our seeds help mitigate risks such as disease, insect, weed, and extreme weather pressures, all while promoting sustainable farming practices that protect and enhance our planet. Join our mission of revolutionizing food security and transforming agriculture.

Job Description

At Syngenta, our goal is to build the most collaborative and trustworthy team in agriculture, providing top-quality seeds and innovative crop protection solutions that improve farmers' success. We invite you to help shape the future of agriculture and play a role in safely feeding the world while caring for our planet.

Syngenta's Bioinformatics Team is seeking a Protein Design Intern in Durham, NC. This internship role will be part of a high-performance scientific team, developing cutting-edge skills in computational protein design to deliver innovative solutions for agricultural biotechnology.

As part of Syngenta's Emerging Talent Program, you will gain hands‑on experience, exposure to day‑to‑day business operations, and opportunities to apply your academic knowledge to real-world challenges while developing your professional skills.

Accountabilities:

• Apply structural bioinformatics methods to discover novel proteins.
• Develop computational workflows that integrate sequence- and structure‑based search algorithms to identify and rank protein candidates.
• Leverage protein structure‑based search workflows using tools such as FoldSeek, ESMFold, and Boltz.
• Perform structural analysis and annotation of protein candidates.
• Develop Python/Bash scripts for data processing and visualization.
• Document workflows, create user guides, and present findings to cross‑functional teams.
• Collaborate with other scientists to refine research strategies based on biological insights.
• Share results and learnings at team meetings and educate team members on workflows and results.

Qualifications

Required Qualifications:

Education:

• Current MS or PhD student in Bioinformatics, Computational Biology, Structural Biology, or a related field.

Technical:

• Proficiency in Python and/or R for bioinformatics (PyRosetta a plus).
• Familiarity with protein structure prediction methods (AlphaFold2, ESMFold, Boltz).
• Familiarity with protein structure visualization (PyMOL or ChimeraX).
• Experience with Linux/Unix command-line environments.
• Knowledge of sequence analysis tools (BLAST, alignment methods).

Analytical :

• Ability to work with large datasets and implement reproducible computational workflows.
• Strong problem‑solving skills and attention to detail.
• Effective written and verbal communication skills.

Desired Qualifications:

• Experience with protein structure comparison tools (TM-align, FoldSeek).
• Experience with protein function prediction tools (InterProScan or ESM‑based methods).
• Knowledge of protein databases (PDB, UniProt, AlphaFoldDB, ESM Metagenomic Atlas).
• Experience with HPC or cloud computing (e.g., AWS).
• Self‑motivated, with the ability to work independently and collaboratively.
• Enthusiasm for learning new computational methods and tools.
• Experience presenting technical work to multidisciplinary audiences.