Protein Biochemistry & IDR Production Scientist (RA II/III)

Buck Institute for Research on Aging; Novato (CA); On-site; USD 65,000 - 90,000; Full time

Job summary

The Buck Institute for Research on Aging in Novato, California, is seeking an experienced Research Associate (level II/III) to support large-scale IDR protein production and biochemical characterization. The role emphasizes hands-on expression, purification, QC, and collaboration with postdoctoral researchers and collaborators.

Candidates should have substantial recombinant protein experience, strong organization, and the ability to develop reproducible workflows in a fast-paced,

Qualifications

• Bachelor's or Master's degree in biochemistry, molecular biology, biotechnology, chemistry, protein science, or a related field, with substantial relevant research experience.
• Extensive hands-on experience in recombinant protein expression and purification.
• Demonstrated ability to independently execute established protocols and troubleshoot technically challenging experiments.
• Strong laboratory organization, record keeping, and sample-management skills.
• Experience managing multiple experimental samples or workflows in parallel.
• Ability to work collaboratively in a fast-moving multidisciplinary research environment.

Responsibilities

• Carry out protein expression, purification, and QC for IDR-containing proteins in human cells.
• Optimize purification and handling of unstable, aggregation-prone, or heterogeneous proteins.
• Perform routine and advanced protein characterization and maintain QC criteria across batches.
• Prepare and document samples for transfer to collaborating labs (single-molecule, HDX-MS, interactome).
• Support in vitro protein interactions, condensation, aggregation, and binder-characterization experiments.
• Maintain detailed inventories, batch records, QC documentation, and transfer manifests.
• Assist with implementation and scaling of reproducible experimental workflows.
• Collaborate with the postdoctoral fellow to troubleshoot problems and improve throughput.
• Contribute to preparation of technical reports and milestone documentation.

Skills

Protein expression

Protein purification

Troubleshooting

Lab organization

Record keeping

Team collaboration

Education

Bachelor's/Master's in Biochemistry or related

Tools

Affinity chromatography

Ion exchange

SEC

Mass spectrometry prep

HDX-MS prep

Protein formulation

Job description

The Buck Institute for Research on Aging in Novato, California, is seeking an experienced Research Associate (level II/III) to support large-scale IDR protein production and biochemical characterization. The role emphasizes hands-on expression, purification, QC, and collaboration with postdoctoral researchers and collaborators.

Candidates should have substantial recombinant protein experience, strong organization, and the ability to develop reproducible workflows in a fast-paced,