Postdoc: IDR Biophysics & Protein Structure

Buck Institute; Novato (CA); On-site; USD 74,000 - 81,000; Full time

Benefits offered by this job

Medical/dental/vision benefits

401(k) employer contribution

Student debt repayment option

Job summary

Buck Institute in Novato, CA seeks Postdoctoral Researchers to join a multidisciplinary program studying intrinsically disordered proteins and regions (IDPs/IDRs). You will develop purification workflows and perform biophysical analyses, collaborating with computational scientists and external partners.

Successful candidates have Ph.D. in relevant fields and hands-on protein expression/purification experience, with an emphasis on IDRs.

Qualifications

• Ph.D. in biochemistry, molecular biology, structural biology, chemical biology, biophysics, protein science, or a related discipline.
• Strong hands-on experience with recombinant protein expression, purification, and biochemical characterization.
• Demonstrated ability to independently troubleshoot experimental workflows.
• Strong quantitative and organizational skills.
• Ability to work effectively within a multidisciplinary and multi-institutional team.

Responsibilities

• Develop and optimize purification and sample-preparation workflows suitable for IDR-containing proteins for measurements including single-molecule profiling, HDX-MS, mass spectrometry, and other structural/biophysical assays.
• Perform biochemical and biophysical characterization of purified proteins and assess sample quality, stability, oligomeric state, and conformational behavior.
• Develop and perform in vitro assays examining IDR interactions, condensation, aggregation, and responses to candidate binders or small molecules.
• Work with computational team members to interpret experimental results in the context of predicted conformational ensembles.
• Maintain rigorous experimental records and contribute to milestone reports, manuscripts, presentations, and publications.
• Help mentor research associates and junior laboratory members involved in the project.

Skills

Biochemistry

Molecular biology

Structural biology

Biophysics

Protein science

Education

PhD in biochemistry or related field

Tools

HDX-MS

SEC

Cryo-EM

NMR

Mass spectrometry

Job description

Buck Institute in Novato, CA seeks Postdoctoral Researchers to join a multidisciplinary program studying intrinsically disordered proteins and regions (IDPs/IDRs). You will develop purification workflows and perform biophysical analyses, collaborating with computational scientists and external partners.

Successful candidates have Ph.D. in relevant fields and hands-on protein expression/purification experience, with an emphasis on IDRs.