Process Scientist

SiPhox Health; Burlington (MA); On-site; USD 120,000 - 168,000; Full time

Benefits offered by this job

Equity

Health Insurance

401K

Gym Membership

Job summary

SiPhox Health in Burlington, MA is seeking a Process Scientist with surface chemistry expertise to drive immunoassay development on our at‑home diagnostics platform. You will design surface chemistries, troubleshoot fouling, and collaborate with product, engineering, and manufacturing teams to transfer processes into scalable manufacturing.

You will lead experimental design, data analysis, and technical reporting while mentoring junior scientists and contributing to invention disclosures and

Qualifications

• PhD in Chemistry, Materials Science, Biochemistry, Bioengineering, Physics, or a closely related field.
• 6+ years of relevant industry experience in surface chemistry, materials science, or biomolecular interfaces in life sciences or diagnostics.
• Deep expertise in surface chemistry, polymer chemistry, and biomolecule–surface interactions.
• Strong publication and presentation record, with contributions to patents or novel methodologies.
• Ability to work independently in experimental planning, execution, and data interpretation.

Responsibilities

• Design, develop, and evaluate novel surface chemistry approaches for immunoassay applications.
• Design and evaluate surface chemistry on microfluidic and lab‑on‑chip devices, considering geometry and flow effects on performance.
• Troubleshoot fouling and non‑specific binding issues.
• Lead product development efforts, including experimental design, prototyping, testing, and data analysis.
• Transfer surface chemistry solutions from research to product development and manufacturing in collaboration with process teams.
• Mentor junior scientists and contribute to invention disclosures and patent work.
• Prepare high‑quality reports and presentations summarizing findings for decision making.

Skills

Surface chemistry

Materials science

Biomolecule interactions

Independent work

Publications/patents

Education

PhD in Chemistry, Materials Science, Biochemistry, Bioengineering, Physics or related

Tools

AFM

Ellipsometry

FTIR

SEM

TOF-SIMS

XPS

Job description

SiPhox Health is building a first-of-its-kind consumer diagnostics platform that brings complex biochemical analysis into the home through integrated silicon photonics, microfluidics, embedded systems, and advanced assay development.

We are building an ambitious, multiplexed clinical-grade immunoassay menu on our at-home diagnostics platform and are seeking a Process Scientist with surface chemistry expertise, a can-do attitude, logical reasoning, and meticulous attention to detail. This is a rare opportunity to join a high-growth startup at its first major inflection point — with a validated, first-generation platform ready for commercialization and scale-up, alongside active next-generation development.

You will play a critical role in driving both research and commercialization of our diagnostic devices, operating with a high degree of independence while collaborating cross-functionally across the organization.

What You’ll Own

Surface Chemistry & Assay Development

• Design, develop, and evaluate novel surface chemistry approaches to enable immunoassay applications.
• Design and evaluate novel surface chemistry solutions on microfluidic and lab-on-chip devices, with a strong understanding of how device geometry and flow conditions influence surface performance and assay outcomes.
• Troubleshoot performance issues related to surface fouling and non-specific binding.
• Identify and resolve experimental challenges related to assay design, protocol execution, reagent selection, and surface performance.

Product & Process Development

• Define and lead product development efforts, including experimental design, prototyping, functional testing, and data analysis.
• Support the transfer of surface chemistry solutions from research into product development and manufacturing, in close collaboration with process development and operations teams.
• Contribute innovative ideas and technical insight to early-stage concept development and feasibility assessments.
• Maintain hands-on scientific leadership, setting the direction for laboratory experimentation and troubleshooting while mentoring junior scientists and guiding their technical development.
• Collaborate effectively with colleagues in product management, assay development, engineering, and manufacturing to ensure alignment and successful execution.
• Contribute technical expertise to invention disclosures and patent applications, in collaboration with the IP legal team and senior technical leadership.
• Prepare and deliver high-quality technical reports and presentations that summarize findings, support decision-making, and document development progress.

And any other assigned duties as determined by leadership.

What We’re Looking For

Required Qualifications

• PhD in Chemistry, Materials Science, Biochemistry, Bioengineering, Physics, or a closely related field.
• 6+ years of relevant industry experience in surface chemistry, materials science, or biomolecular interfaces within life sciences or diagnostics.
• Deep expertise in surface chemistry, polymer chemistry, and biomolecule–surface interactions.
• Strong publication and presentation record, with contributions to patents or novel methodologies.
• Ability to operate with a high degree of independence in experimental planning, execution, and data interpretation, requiring minimal day-to-day supervision.
• Strong scientific judgment to extrapolate from existing expertise and address novel or ambiguous technical challenges.
• Proactive mindset to identify risks, knowledge gaps, and opportunities, and to propose data-driven paths forward that shape project scope and organizational priorities.
• Clear, purposeful communication across disciplines to enable alignment, informed decisions, and efficient collaboration.
• Authorization to work in the U.S. without sponsorship.

Preferred Qualifications

• Familiarity with microfluidic device design principles, including channel geometry, surface-to-volume ratios, and flow dynamics; experience with device fabrication or commercial lab-on-chip platforms is a plus.
• Familiarity with surface analytical techniques such as AFM, ellipsometry, FTIR, SEM, TOF-SIMS, and XPS.
• Familiarity with manufacturing constraints, process transfer, or scale-up.

KPIs (Success Measures)

• Experimental throughput and quality — number of well-controlled, documented experiments completed per quarter; reproducibility and scientific rigor of results.
• Assay and surface chemistry milestones — on-time delivery of defined development milestones (e.g., achieving target binding performance, completing process transfers).
• Cross-functional collaboration — quality and timeliness of technical documentation, presentations, and knowledge transfer to manufacturing and product teams.
• Innovation contribution — invention disclosures, patent applications, or novel methodologies introduced.

Who Thrives Here

You thrive in fast-paced, highly collaborative environments where priorities evolve quickly. You set ambitious goals and consistently deliver outstanding, measurable results. Youact with absolute personal integrity, humility, and a passion for excellence in both science and execution. You’re a calculated risk-taker who challenges conventional solutions and approaches problems from first principles.

Why Join SiPhox Health

• Help bring a first-of-its-kind at-home diagnostics platform to market.
• Work alongside multidisciplinary engineering and scientific teams solving complex technical challenges.
• Opportunity for expanded scientific leadership responsibilities as the organization scales.
• Competitive compensation, equity, and benefits (including Lifetime Fitness membership).

Department: Research & Development / Assay Development

Work location: Burlington, MA (on-site)

Salary Range: $120,000 to $168,000

• 401K
• Health Insurance
• Vision Insurance
• Health Savings Account
• Health Flexible Savings Account
• Dependent Care Flexible Savings Account
• Life Insurance
• Paid Time Off
• Long Term Disability
• Equity
• Gym Membership (Lifetime Fitness — one block from the office)

Physical Requirements

• Ability to lift up to 20 pounds.
• This role involves physical activity and routine handling of chemicals. Candidates must adhere to all laboratory safety protocols and be comfortable using appropriate personal protective equipment (PPE).

Equal Opportunity Employer

SiPhox Health is an equal opportunity employer committed to building an inclusive workplace. Applicants of all backgrounds and experiences are encouraged to apply.