Senior Chemist

SiPhox Health; Burlington (MA); On-site; USD 120,000 - 168,000; Full time

Benefits offered by this job

401K

Health Insurance

Vision Insurance

Health Savings Account

Flexible Spending Account

Job summary

SiPhox Health is seeking a Chemist/Senior Chemist to advance organic and solid-phase chemistry for at-home diagnostics. You will develop bioconjugates, optimize conjugation methods, and validate products with analytical tools to support R&D and commercialization.

This in-person role at our Burlington, MA site focuses on antibody-based conjugates and scalable processes. Preferred candidates hold an MS/PhD in relevant fields with 2–8 years of conjugation and purification experience, plus

Qualifications

• M.S. or Ph.D. in Organic Chemistry, Biochemistry, or related field, or equivalent industry experience.
• 2–8 years of experience in production, purification, and characterization of conjugate molecules at research/medium scales.
• Experience with bioconjugates or antibody–drug conjugates, including site-specific approaches.
• Strict adherence to laboratory safety protocols.

Responsibilities

• Synthesize bioconjugates and nanoparticles using established chemistries.
• Develop new bioconjugation and nanoparticle conjugation methodologies.
• Optimize protein, antibody, and nanoparticle conjugation methods for performance and scalability.
• Purify bioconjugates using SEC, IEX, affinity chromatography, and HIC.
• Characterize conjugates by UV/Vis, fluorescence, HPLC, and MS.
• Perform functional verification through internal immunoassay configurations.
• Maintain compliant lab records per ISO 13485 and FDA guidelines.

Skills

Bioconjugation

Purification

Characterization

Lab safety

Education

MS/PhD in Organic Chemistry or Biochemistry

Tools

HPLC

Mass Spectrometry

SEC

IEX

HIC

Job description

SiPhox Health is building a first-of-its-kind consumer diagnostics platform that brings complex biochemical analysis into the home through integrated silicon photonics, microfluidics, embedded systems, and advanced assay development. Our chip-based solution integrates state-of-the-art biochemistry, photonics, electronics, and microfluidics to deliver the power of large laboratory instruments in a portable device.

We are seeking an exceptional Chemist or Senior Chemist with solid expertise in organic and solid-phase chemistry, along with deep experience in bioconjugation and purification — particularly with antibodies — to join an exciting, externally funded project pushing the boundaries of continuous monitoring of complex biological systems. In this role, you will develop novel chemistry schemes, validate them using analytical tools and internal assay configurations, and support both R&D and commercialization efforts across the organization. If you are passionate about driving innovation and making a tangible impact in biotechnology, we invite you to join us at this frontier.

What You\'ll Own

Synthesis & Conjugation

• Synthesize bioconjugates and nanoparticles using established chemistries.
• Develop new bioconjugation and nanoparticle conjugation methodologies.
• Optimize protein, antibody, and nanoparticle conjugation methods for performance and scalability.

Purification & Characterization

• Purify bioconjugates and nanoparticle conjugates using techniques including size exclusion chromatography (SEC), ion-exchange chromatography (IEX), affinity chromatography, and hydrophobic interaction chromatography (HIC).
• Optimize purification methods for yield, purity, and reproducibility.
• Characterize bioconjugates and nanoparticle conjugates using UV/Vis spectroscopy, fluorescence, HPLC, and mass spectrometry (MS).
• Perform functional verification through internal immunoassay configurations.

Documentation & Compliance

• Maintain accurate, complete, and timely laboratory records and notebooks in compliance with ISO 13485, FDA 21 CFR 820, 21 CFR Part 11, EU Medical Device Regulation 93/42/EEC, and EU MDR/2017, where applicable.
• Stay current with relevant scientific literature; conduct project-related information searches and literature reviews as needed.
• Demonstrate excellent written and verbal communication skills; maintain formal company documentation as required.

Problem Solving & Collaboration

• Solve complex technical problems by analyzing situations and data, exercising sound scientific judgment within broadly defined practices and policies to reach appropriate conclusions and follow-up actions.
• Collaborate cross-functionally with R&D, assay development, engineering, and operations teams.

Note: SiPhox Health is a fast-paced startup. This is a fully in-person role that may occasionally require extended hours to meet project deadlines.

What We\'re Looking For

Required Qualifications

• M.S. or Ph.D. in Organic Chemistry, Biochemistry, or a related field, or equivalent industry experience.
• 2–8 years of experience in the production, purification, and characterization of conjugate molecules at research and medium scales.
• Experience with bioconjugates or drug delivery modalities such as targeted peptides, oligonucleotides, or antibody–drug conjugates (ADCs), including site-specific approaches.
• In-depth familiarity with laboratory equipment and strict adherence to laboratory safety protocols.

Preferred Qualifications

• Direct experience in immunoassay method development, optimization, and data analysis; proficiency in Python, R, or MATLAB is a plus.
• CLIA laboratory experience.
• Experience with point-of-care and/or at-home diagnostic devices.
• Experience with label-free sensors.
• Experience with biochips, microarrays, and microfluidics.

KPIs (Success Measures)

• Synthesis and purification throughput — number of well-controlled, documented conjugation and purification runs completed per quarter; yield, purity, and reproducibility of results.
• Characterization rigor — quality and completeness of analytical data (UV/Vis, HPLC, MS) supporting conjugate validation.
• Compliance and documentation — timeliness and completeness of laboratory records per ISO 13485 / FDA 21 CFR 820 / 21 CFR Part 11 standards.
• Cross-functional collaboration — quality and timeliness of technical support provided to R&D, assay development, engineering, and operations teams.

Who Thrives Here

You set ambitious goals and consistently deliver outstanding, measurable results. You demonstrate absolute personal integrity and credibility, and thrive in a small-team environment while delivering outsized impact. You\'re driven by a genuine passion for scientific excellence — a calculated risk-taker who challenges conventional approaches and pursues creative solutions. You\'re a strategic thinker with the ability to approach problems from first principles.

Why Join SiPhox Health

• Help bring a first-of-its-kind at-home diagnostics platform to market.
• Work alongside multidisciplinary engineering and scientific teams solving complex technical challenges.
• Opportunity for expanded scientific leadership responsibilities as the organization scales.
• Competitive compensation, equity, and benefits (including Lifetime Fitness membership).

Work location: Burlington, MA (on-site)

Salary Range: $120,000 - $168,000

• 401K
• Health Insurance
• Vision Insurance
• Health Savings Account
• Health Flexible Savings Account
• Dependent Care Flexible Savings Account
• Life Insurance
• Paid Time Off
• Long Term Disability
• Equity
• Gym Membership (Lifetime Fitness — one block from the office)

Physical Requirements

• Ability to lift up to 20 pounds.
• This role involves physical activity and routine handling of chemicals. Candidates must adhere to all laboratory safety protocols and be comfortable using appropriate personal protective equipment (PPE).

Equal Opportunity Employer

SiPhox Health is an equal opportunity employer committed to building an inclusive workplace. Applicants of all backgrounds and experiences are encouraged to apply.