Process Research Scientist I: Bioorganic Route Development

Promega Corporation; San Luis Obispo (CA); On-site; USD 98,000 - 147,000; Full time

Job summary

Promega Corporation in San Luis Obispo seeks a highly motivated organic chemist to design and explore multi-step routes for bioapplications, with emphasis on safe, reproducible, and cost-effective development.

You will work with a cross-functional team across Promega's San Luis Obispo and Madison sites, advancing proof-of-concept to full product realization through quality-by-design and innovative problem solving.

Qualifications

• PhD in Organic Chemistry with 0-2 years’ experience with multi-step organic synthesis, purification and characterization, or Master’s Degree with 2-4 years strong experience in process development in organic synthesis.
• Ability to create independent thought and problem solving with strong organic chemistry knowledge of scientific principles and concepts required.
• Ability to independently design and explore a safe, reliable synthetic route potential for manufacturing a given molecule/product.
• Ability to optimize reaction conditions, potentially leading to a reproducible manufacturing protocol.
• Ability to investigate potential critical material attributes linked to the critical performance.
• Ability to work closely with new product realization team and execute a quality-by-design chemical process in safe, reproducible and cost-effective manner.
• Ability to scale up synthesis of molecules in relatively large scale.
• Strong interpersonal and communication skills.
• Ability to present research activities in a scientific manner to the group, management team and outside customers.
• Ability to write manuscripts for peered review journals.
• Demonstrated proficiency in digital tools and technology, including Microsoft applications and mobile platforms, with the ability to adapt and leverage emerging technologies, such as artificial intelligence, to improve efficiency, automation, and collaboration.

Responsibilities

• Design and explore multi-step chemical process for a variety of biocompatible organic molecules in collaborating with chemists, analysts, and biologists.
• Purify synthetic compounds from classic purification methods, including distillation, recrystallization, flash chromatography and prep-HPLC.
• Characterize synthetic compounds by HPLC, LC-MS, NMR, etc. or other methods as needed.
• Identify a safe, robust synthetic route for particular product(s).
• Explore the critical material attributes linked to desired biological function performance in considering aspects of solubility, stability, and chemical safety.
• Work closely within new product realization teams across different departments at Promega’s San Luis Obispo office, integrating with biology team at Promega Madison to deliver the key deliverables for new product realization.
• Execute a quality-by-design chemical process in a safe, reproducible and cost-effective manner suitable for new product realization.
• Apply knowledge and experience to solve complex scientific problems working within an internal team of chemists and biologists and strive for synergistic co-creativity within that team.
• Present scientific results and other reports to small or large groups within the company.
• Interface with highly valued internal and external customers with professionalism.
• Maintain high level of knowledge related to current developments in organic chemistry, chemical biology and life science tool development.
• Complete assigned duties in a safe manner.

Skills

Organic synthesis knowledge

Independent problem solving

Scale-up synthesis

Quality-by-design

Communication

Manuscript writing

Team collaboration

Digital tools

Education

PhD in Organic Chemistry

MS in Chemistry or related field

Tools

ChemDraw

Microsoft Office

Job description

Promega Corporation in San Luis Obispo seeks a highly motivated organic chemist to design and explore multi-step routes for bioapplications, with emphasis on safe, reproducible, and cost-effective development.

You will work with a cross-functional team across Promega's San Luis Obispo and Madison sites, advancing proof-of-concept to full product realization through quality-by-design and innovative problem solving.