Process Development Engineer I, Late-Stage Purification

BioSpace; Village of Tarrytown (NY); On-site; USD 80,000 - 131,000; Full time

Benefits offered by this job

Health insurance

Retirement benefits

Paid time off

Job summary

Regeneron is seeking a Process Development Engineer I to join the Late-Stage Purification Development team in PMPD, on-site in Tarrytown, NY. You will design and execute bench and pilot-scale experiments to advance recombinant protein purification processes and transfer them for GMP manufacturing.

The role requires hands-on purification experience, process automation know-how, and the ability to train peers while ensuring safety and quality.

Qualifications

• Bachelor's or Master's degree in Chemical Engineering, Biochemical Engineering, Biochemistry, or related field.
• Hands-on purification techniques: depth filtration, disc stack centrifugation, column chromatography, virus retentive filtration, ultrafiltration/diafiltration.
• Experience purifying monoclonal antibodies or other biopharmaceuticals.
• Experience with process automation hardware, control logic, and HMIs.
• Team-based, well-organized with multi-project management.
• Preferred: strong protein purification fundamentals and experience with listed tools.

Responsibilities

• Design and execute bench- and pilot-scale experiments.
• Analyze data, draw conclusions, and propose next steps.
• Document results in notebooks and reports; share findings with leadership.
• Serve as purification development SME during manufacturing process transfers for GMP batches.
• Collaborate cross-functionally to enable robust manufacturing processes.
• Support tech development: automate pilot-scale unit operations and optimize bench-scale models.
• Train and mentor peers, co-ops and interns in experiments and data analysis.
• Maintain lab equipment and uphold lab safety standards.

Skills

Experiment design

Data analysis

Documentation

Cross-functional teamwork

Automation experience

Mentoring

Lab safety

Project management

Education

Bachelor's or Master's in Chemical/Biochemical Eng or related

Tools

Akta chromatography

HPLC

UPLC

Empower

Unicorn

JMP

LIMS

Python

Ignition

PI Historian

Job description

Build Our Future Together

At Regeneron, we use science and innovation to develop life‑changing medicines for people with serious diseases. We are seeking a Process Development Engineer I to join our Late‑Stage Purification Development team within Preclinical Manufacturing and Process Development (PMPD) in an on‑site capacity. In this role, you will develop and transfer harvest, affinity chromatography, and viral inactivation processes for recombinant proteins using Quality by Design principles, while collaborating with process development and manufacturing colleagues. This position offers the opportunity to contribute to a fast‑growing, science‑driven organization making a meaningful difference to patients worldwide.

When & Where

Location: Tarrytown, NY

Work model: On-site

Discover Your Role

• Design and execute experiments at bench and pilot scale
• Analyze data, draw conclusions, and propose next steps
• Document results in laboratory notebooks and reports, and share findings with functional area and department leadership
• Serve as purification development subject matter expert during manufacturing process transfer to support successful GMP batches
• Collaborate cross‑functionally with the process development team to enable a robust, cohesive manufacturing process
• Support technology development, such as automating pilot‑scale unit operations, improving bench‑scale process models, building historical data workflows, and evaluating new raw materials, equipment, or techniques
• Train and mentor peers, co‑op students, and interns in running experiments, analyzing data, and documenting results
• Contribute to lab equipment maintenance and lab safety to keep our working environment safe, effective, and efficient

This Role Requires

• Bachelor's or Master's degree in Chemical Engineering, Biochemical Engineering, Biochemistry, or a related field, with 0-2 years of recombinant protein purification experience
• Hands‑on experience with techniques such as depth filtration, disc stack centrifugation, column chromatography, virus retentive filtration, ultrafiltration/diafiltration, and buffer preparation
• A solid understanding of, and practical experience in, purifying monoclonal antibodies or other biopharmaceuticals
• Experience with process automation, such as hardware, control logic, and/or HMI development
• Thrive in a team‑based, collaborative environment; must be well‑organized and can manage multiple projects efficiently
• Preferred: strong fundamental understanding of protein purification techniques
• Preferred: experience with Akta chromatography systems, HPLC, UPLC, Empower, Unicorn, JMP, LIMS, Python, Ignition, and PI Historian

Salary Range (annually)

$80,300.00 - $131,100.00

Where necessary, we disclose salary ranges for roles in all countries in which we operate.

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role:

• annual bonuses or other incentive plans
• equity awards
• pension or retirement benefits
• 401(k) company match
• health and wellness programs
• fitness centers
• insurance benefits (e.g. medical, dental, vision, life and disability)
• paid time off
• family support benefits

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/.

For jobs in Canada: this posting is for an existing position.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.