Process Development Chemist III – Oligonucleotide Analysis

Socket.dev; Verona (WI); On-site; USD 78,000 - 90,000; Full time

Job summary

Arrowhead Pharmaceuticals, Inc. in Wisconsin is seeking an Associate Scientist III in the Process Development Chemistry Group to focus on oligonucleotide analysis and synthesis development.

This is ideal for someone with an organic or biological chemistry background who enjoys exploring novel synthesis and purification technologies. You will perform analytical techniques (HPLC, UV/Vis, LC-MS), calibrate instruments, analyze data, and help scale new procedures toward manufacturing.

Qualifications

• BS or MS in chemistry or biochemistry with an excellent understanding of organic and analytical chemistry.
• At least 4 years of experience working in a chemistry laboratory setting.
• Familiar with analytical instrumentation, test methodologies/validations, data acquisition systems, and cGMP policies and practices.
• Ability to correctly analyze data/results and interpret outcome of experiments and to propose appropriate follow-up.
• Excellent verbal and written communication skills
• Strong problem-solving skills
• Eagerness to learn new techniques
• Experience with small-molecule and macromolecule analytical techniques (e.g., HPLC, UV-Vis spectrophotometry, mass spectrometry, NMR, etc.)

Responsibilities

• Independently provide accurate analytical results in support of new and on-going projects with a focus on process characterization.
• Perform analytical techniques, such as HPLC, UV/Vis, LC/MS, etc.
• Handle, analyze and characterize chemicals, pharmaceuticals, and related organic molecules.
• Analyze data/results and interpret outcome of experiments and independently propose appropriate follow-up.
• Calibrate, maintain, and troubleshoot all analytical equipment.
• Work closely with senior chemists on development of new synthetic approaches to desired compounds with an eye toward large-scale synthesis
• Cooperate with other chemists in the group in preparation of complex organic constructs
• Analyze small-molecule and macromolecular targets using standard methods
• Maintain a well-documented laboratory notebook
• Prepare documentation for transfer of new technologies to the Manufacturing group
• Track progress against project timelines, generate regular status updates, and communicate progress and issues to management, including presentation of findings at team meetings
• Coordinate delivery of materials both internally and externally

Skills

Analytical chemistry

Data interpretation

Communication

Problem solving

Learning agility

HPLC familiarity

Education

Bachelor's or Master's in Chemistry or Biochemistry

Tools

HPLC

UV-Vis

LC-MS

NMR

Job description

Arrowhead Pharmaceuticals, Inc. in Wisconsin is seeking an Associate Scientist III in the Process Development Chemistry Group to focus on oligonucleotide analysis and synthesis development.

This is ideal for someone with an organic or biological chemistry background who enjoys exploring novel synthesis and purification technologies. You will perform analytical techniques (HPLC, UV/Vis, LC-MS), calibrate instruments, analyze data, and help scale new procedures toward manufacturing.