Process Development Associate

Arbor Biotechnologies, Inc; Cambridge (MA); On-site; USD 70,000 - 90,000; Full time

Job summary

A next-generation gene editing company in Cambridge is seeking a Process Development Associate to support the manufacturing of therapeutic CRISPR products. This role focuses on translating developmental processes into commercial reality, applying engineering expertise to create high-quality products for patients. If you're passionate about innovation and eager to contribute to lifesaving therapies, this opportunity is for you.

Qualifications

• 1-2 years of laboratory experience in a process development or manufacturing role.
• Experience with bioproduction unit operations highly preferred.
• Organized and diligent mindset with ability to learn new skills.

Responsibilities

• Provide process engineering/production support of CRISPR products.
• Execute non-GMP manufacturing processes end-to-end.
• Collaborate with the analytical development team for quality methods.

Skills

Process analytics

Suspension cell culture

Clarification

Filtration

Chromatography

Education

Bachelor's degree in Chemical Engineering

Bachelor's degree in Biomedical Engineering

Bachelor's degree in Biochemistry

Bachelor's degree in Biotechnology

Job description

Arbor Biotechnologies, a next-generation gene editing company based in Cambridge, MA, is advancing a pipeline of novel gene editing therapeutics to address a wide range of genetic conditions – from the ultra-rare to the most common genetic diseases. The company’s unique suite of optimized gene editors goes beyond the limitations of early editing technologies to unlock access to new gene targets and has fueled a robust pipeline of first-in-class assets focused on diseases of high unmet need. With Arbor’s lead program, ABO-101 for the treatment of primary hyperoxaluria type 1, progressing into clinical trials, the company continues to focus their research and development efforts on genomic diseases of the liver and CNS for which there are no existing functional cures. For more information, please visit: arbor.bio.

Who are you?

Passionate, determined, and accountable. Curious, resourceful, innovative, forward thinking, and resilient. Authentic, humble, open-minded and puts team above self. At Arbor, our people embrace these qualities, so if this sounds like you then please read on!

About the Role:
We are seeking a Process Development Associate to join the Delivery and Process Sciences team at our Cambridge site. This person will provide process engineering/ production support of therapeutic CRISPR gene editing products. Our mission is to translate developmental processes to commercial reality for patients through scientific expertise and engineering innovation.

What You Can Expect:

• Apply scientific and engineering knowledge to manufacturing process design, development, and understanding
• Execute non-GMP manufacturing processes end-to-end to produce high quality AAV, mRNA, and LNP to support IND-enabling pharmacology studies
• Collaborate with the analytical development team to establish methods demonstrating quality of drug substance and drug product
• Maintain accurate and detailed documentation of experimental procedures, batch records, and process deviations in accordance with regulatory and quality guidelines

What You Bring:

• Bachelor’s degree in Chemical Engineering, Biomedical Engineering, Biochemistry, Biotechnology, or a related field.
• 1-2 years of laboratory experience in a process development or manufacturing role
• Experience with bioproduction unit operations including suspension cell culture, clarification, filtration, and chromatography
• Experience with chemoenzymatic reactions highly preferred
• Working knowledge of process analytics
• An organized, diligent mindset with the ability to learn new skills on the job

Our Values:

Our values govern the work we do at Arbor, and we’re hoping that they resonate as strongly with you as they do with us!

· Purposeful Action: Start with The Why

· Bold Resilience: Adopt a Growth Mindset

· Humble Authenticity: Start in the Heart

We promote diversity and inclusion not just in our recruitment processes, but in everything we do. We’re an equal opportunity employer and we will continue to ensure our recruitment process is free of bias and our workplace is inclusive, positive, and free of discrimination and respecting of all backgrounds and beliefs.