Senior Associate Scientist, Cellular Process Development Lexington, MA

KSQ Therapeutics, Inc.; Massachusetts; Hybrid; USD 75,000 - 100,000; Full time

Job summary

KSQ Therapeutics is seeking a Senior Associate Scientist to join its Adoptive Cell Therapy team. The ideal candidate will have a strong background in T cell immunology, skill in CRISPR-Cas9 technology, and proven experience in cell culture and molecular biology. You will contribute to innovative cancer therapies through rigorous scientific research and collaboration with cross-functional teams.

Qualifications

• 2-3 years of experience in a relevant academic or biopharmaceutical setting.
• Experience in designing and interpreting flow cytometry results preferred.
• Experience in CRISPR/Cas9 gene-editing tools is a plus.

Responsibilities

• Contribute to the development of engineered T cell therapy pipeline.
• Design and execute cell- and molecular-based assays for validation.
• Timely documentation of development reports and technical presentations.

Skills

Cell culture

CRISPR-Cas9 technology

T cell immunology

Flow cytometry

Molecular biology techniques

Attention to detail

Communication skills

Education

B.S. or M.S. in biology, immunology, or relevant field

Job description

Senior Associate Scientist, Cellular Process Development

Lexington, MA

At KSQ Therapeutics, we seek to understand the role of every human gene in each disease, each tissue, and each cell that we study. This comprehensive approach has resulted in a massive, experimentally derived dataset that we have found to be remarkably predictive of past successes and failures in oncology and immuno-oncology product development. Utilizing this approach, we also identified a number of opportunities for the development of new medicines. As a result, we have aggressively invested in these distinct, highly validated pathways for new drug development with the expectation that the medicines we create may become the next breakthrough products for patients.

Founded in late 2015, KSQ is a clinical-stage biotech that has rapidly advanced the field of CRISPR-enabled functional genomics, from in vitro cell autonomous screens to more complex genome-scale screens of immune cells in vivo. The company has expanded the scope of its technology to include multiple cell types and to unlock areas beyond oncology. KSQ is led by a team of accomplished industry experts in drug discovery and development.

KSQ is led by a team of accomplished industry experts in drug discovery and development. When you join KSQ, you're not just landing a new gig. You become part of a team of doers, thinkers and collaborators who embrace and live by our values:

• COLLABORATION
• AUTHENTICITY
• RESILIENCE
• EXCELLENCE

Position Summary:

KSQ Therapeutics, Inc. is seeking a self-motivated and dependable Senior Associate Scientist to join our Adoptive Cell Therapy team. Our ideal candidate thrives in a research environment that demands scientific rigor and technical excellence. Applicants with an interest in T cell immunology and expertise in cell culture, CRISPR-Cas9 technology and cell biology are strongly encouraged to apply.

Key responsibilities include the following:

• Contribute to the development of KSQ’s engineered eTIL (Tumor Infiltrating lymphocytes) cell therapy pipeline, including the design and execution of process development activities
• Design and execute cell- and molecular-based assays for validation of T cell therapy edits
• Timely documentation of development reports and ELNs
• Develop and deliver scientific presentations and reports in a fast and efficient manner
• Prepare and present technical data and technical reports for internal use and to external partners
• Provide technical support to cross-functional groups and external collaborators
• Participate in various aspects of small company capability building

Requirements

• B.S. or M.S. in biology, immunology, or relevant field
• 2-3 years of experience in a relevant academic or biopharmaceutical setting
• Ability to commute to site location in Lexington, MA. Position will be hybrid with approximately 80% onsite (primarily in the lab), 20% remote.
• Proficiency in mammalian cell culture and aseptic cell culture techniques
• Experience in designing, performing, and interpreting the results of multicolor flow cytometry for phenotyping and functional analysis of immune cells preferred
• Experience with technology transfer to a CDMO preferred
• Hands-on experience in diverse cell biology techniques (cell isolation, proliferation assays, T cell expansion, cytotoxicity, functionality assays and etc.) and molecular biology techniques
• Experience in CRISPR/Cas9 gene-editing tools and cloning techniques is a plus
• Demonstrated commitment to quality and great attention to details, especially pertaining to review of reports, experimental results and raw data.
• Ability to maintain a clean and organized lab space, including but not limited to inventory management via a Kanban min/max system and 5S methodology
• Excellent verbal/written communication and presentation skills
• Ability to contribute to multiple parallel projects under demanding timelines
• A record of achievement in research and scientific creativity in the areas of immunology, oncology, inflammation, immuno-oncology, and/or drug discovery
• Must be enthusiastic, curious, collaborative & open-minded
• Must be able to give and receive constructive feedback
• Must have patience, integrity and honesty

KSQ Therapeutics is proud to be an Equal Opportunity Employer.

COVID-19 vaccination is a condition of employment at KSQ, subject to reasonable accommodation where required by law. Employees must be fully vaccinated by date of hire to be considered.

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