Process Dev Engineering Scientist

Vertex Pharmaceuticals Incorporated; Boston, Auburn (MA, ME); On-site; USD 105,000 - 159,000; Full time

Job summary

Join a forward-thinking biotechnology company dedicated to transforming lives through scientific innovation. As a Scientist in the Process Development team, you will contribute to the cutting-edge development of stem cell culture media for gene therapy applications. This role offers the chance to lead impactful projects that enhance process robustness and reduce costs in commercial-scale manufacturing. With a commitment to research and development, you will work alongside talented professionals in a collaborative environment, driving advancements in therapies that address significant unmet medical needs. If you are passionate about making a difference in patients' lives, this is the opportunity for you.

Benefits

Medical Benefits

Dental Benefits

Vision Benefits

Generous Paid Time Off

Educational Assistance Programs

Commuting Subsidy

401(k) Plan

Annual Bonus

Equity Awards

Flexible Work Options

Qualifications

• PhD or MS/BS with relevant industry experience in stem cell biology.
• Experience with medium development and mammalian cell culture.
• Strong knowledge of DoE and bioreactors.

Responsibilities

• Lead experiments to evaluate new medium components for cell culture.
• Collaborate with teams on project goals and share results.
• Ensure compliance with lab safety procedures and mentor junior staff.

Skills

Medium Development

Mammalian Cell Culture

Analytical Tools

Design of Experiments (DoE)

Bioreactor Knowledge

cGxP

Communication Skills

Organizational Skills

Education

PhD in Stem Cell Biology or related field

MS with 4+ years of experience

BS with 6+ years of experience

Tools

High Throughput Screening Platforms

Electronic Notebook Systems

Job description

Job Description

General Summary:

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people living with serious diseases, with a focus on specialty markets. We invest in diseases where there is a significant unmet need and we can have a transformative impact for patients, not just an incremental benefit. We invest the majority of our resources in research and development (R&D) to discover new medicines, because we believe the true value in our industry is unleashed through scientific innovation. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treat-and even cure-several of the diseases Vertex is focused on, including sickle cell disease and type 1 diabetes. Our Cell and Genetic Therapies (CGT) teams bring together the best biology, technologies, and enhanced manufacturing capabilities to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible.

CGT is seeking a Scientist to join our Process Development team to support our media development effort. The focus of this positionis to contribute to the innovative stem cell culture medium development and optimization for cell and gene therapy applications, collaborating with high performing teams. This position will provide opportunities to independently lead scientific innovation projects to advance media optimizations, with impactful deliverables on CoG reduction for cell therapy commercial scale manufacturing, as well as process robustness improvement through more advanced process fundamental understandings. The position will be based in Boston, MA.

Duties and Responsibilities:

• Lead the design and execution of experiments to evaluate new medium components and supplements, through assessment of cell culture performance.
• Apply basic and advanced analytical tools including spent media analysis and omics for in-depth fundamental understanding of the process, as well as continuous optimization of stem cell culture medium.
• Contribute to the establishment and utilization of high throughput small scale screening platforms.
• Apply Design of Experiment (DOE) principles for medium development and optimization.
• Collaborate with cross-functional teams, aligning on project goals, sharing results, and fostering a collaborative working environment.
• Ensure data integrity by timely completion of phase-appropriate documentation, including electronic notebook system, development protocols, and technical reports to support future technology transfers and regulatory filings.
• Ensure compliance with lab safety procedures.
• Lead by example, work closely with the team in the lab and conduct hands on experiments.
• Mentor and support junior team members to independently plan and design experiments.

Minimum Requirements

• Degree in Stem Cell Biology, Chemical/Biochemical/Biomedical Engineering, Life Sciences, or related discipline.
• PhD with a minimum of 0-3 years of relevant industry work experience, or a BS with 6+years of industry experience, or a MS with 4+ years of relevant industry experience.
• Strong fundamental knowledge and previous experience of medium development and mammalian cell culture (stem cell culture knowledge and experience are preferred) as well as knowledge of recent advances and challenges in the field.
• Solid knowledge and experience on DoE principled experimental design and execution.
• Strong fundamental knowledge and experience on bioreactors across scales (experience with high throughput and automatic cell culture platforms is highly preferred).
• Must have a working knowledge of cGxP.
• Excellent verbal and written communication skills.
• Ability to handle multiple tasks while meeting timelines and adapting to changing priorities.
• Excellent organizational skills and high attention to detail.
• Participate in weekend work rotation with the broader team.
• Authorized to legally work in the US.

Pay Range:

$105,600 - $158,400

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]