Process chemistry principal scientist chemist

Vertex Pharmaceuticals; Boston (MA); On-site; USD 132,000 - 198,000; Full time

Job summary

Vertex Pharmaceuticals is seeking a skilled peptide chemist to enhance their Process Chemistry lab. The position involves developing synthesis and characterization techniques for peptides and organic compounds, collaborating with partners, and contributing to scientific documentation. Candidates should have a PhD in related fields or equivalent experience, with a strong emphasis on solid-phase synthesis and organic chemistry.

Benefits

Generous paid time off

Educational assistance programs

401(k) matching

Commuting subsidy

Qualifications

• Advanced expertise in organic synthesis and solid-phase peptide synthesis (SPPS).
• Experience managing external CROs/CMOs.
• Experience in nucleic acid modifications and delivery of oligonucleotides is desirable.

Responsibilities

• Synthesize, purify, and characterize small organic compounds and peptides.
• Collaborate with project teams in a cross-functional environment.
• Author or contribute to regulatory submissions and scientific papers.

Skills

Organic synthesis

Peptide synthesis

Communication

Organizational skills

Education

PhD in synthetic organic chemistry or peptide chemistry

MS with 7 years experience

BS with 10+ years experience

Tools

CS-Bio solid phase peptide synthesizers

HPLC

NMR

MS

Job description

Job Description

General Summary:

Vertex is seeking an experienced peptide chemist to join the Process Chemistry group. In this lab-based position you will be responsible for the synthesis, purification, and characterization of small organic compounds, peptides and possibly peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs). In addition, you will assist the tech transfer to external CMOs for phase appropriate development and scale-up.

Key Duties And Responsibilities

• Develop the synthesis, purification, and characterization of small organic compounds, peptides, and oligonucleotides under minimal supervision
• Assist the building of relationships with external partners
• Identify and advocate for innovative synthetic strategies to project teams
• Collaborate with project teams in a cross-functional environment
• Author or contribute to technical documents including regulatory submissions, patents, and scientific papers
• Maintain a high level of expertise via relevant scientific and technical literature, and proactively apply new ideas to research projects.
  
  

Knowledge And Skills

• Advanced expertise in organic synthesis, especially solid-phase peptide synthesis (SPPS)
• Developing and scaling-up solid phase and liquid phase chemistry
• Experience with reverse-phase and/or ion-exchange purification of small molecules or peptides
• Strong organizational and communication skills
  
  

Education And Experience

• PhD 4-6 years of experience, MS degree with 7 years or experience, BS degree with 10+ years of experience (or equivalent education and experience) in synthetic organic chemistry or peptide chemistry Experience managing external CROs/CMOs
• Experience in nucleic acid modifications and delivery of oligonucleotides are highly desirable
• Experience with small- and large-scale CS-Bio solid phase peptide synthesizers (CS136x, CS936, or equivalent) in non-GMP and GMP environments
• Experience with the synthesis, conjugation and purification of phosphorodiamidate morpholino oligomers (PMOs) is highly desired
• Experience independently planning, executing experiments, and interpreting analytical data (H/UPLC, NMR, MS, etc.
  
  

Keywords: Oligonucleotide, process chemistry, solid-phase synthesis, peptide synthesis

Pay Range

$132,000 - $197,900

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation

On-Site Designated

Flex Eligibility Status

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]