Principal Scientist - Upstream Process Development - Onsite - Marlborough, MA

Sartorius; Marlborough (MA); On-site; USD 90,000 - 150,000; Full time

Job summary

An established industry player is seeking a Principal Scientist in Upstream Process Development to drive innovation in biomanufacturing solutions. This role involves designing and optimizing protocols for cell culture, leading cross-functional teams, and developing proposals for process improvements. You will work in a dynamic environment that values personal initiative and collaboration, contributing to the advancement of cutting-edge therapies. Join a team committed to making a real-world impact in healthcare, where your expertise will help translate scientific discoveries into life-saving treatments. This is a unique opportunity to shape the future of biomanufacturing and lead projects that matter.

Benefits

401(k) with company match

Paid vacation and sick time

Flexible work schedules

Health and wellness programs

Professional development opportunities

Team spirit and mutual support

Smart working environment

Company paid benefits

Qualifications

• Ph.D. with 6+ years in relevant field and extensive cell culture expertise.
• Ability to design and implement advanced therapy processes.

Responsibilities

• Design and optimize protocols for cell culture and growth.
• Lead cross-functional teams to scale bioreactor processes.
• Mentor junior staff and manage multiple research projects.

Skills

Cell Culture

Bioreactor Systems

Molecular Biology Techniques

Analytical Skills

Project Management

Technical Writing

Education

Ph.D. in Chemical/Biochemical Engineering

Tools

PCR

qPCR

NGS

ELISA

Flow Cytometry

Job description

Principal Scientist - Upstream Process Development - Onsite - Marlborough, MA

Principal Scientist - Upstream Process Development - Onsite - Marlborough, MA

Sartorius’ Emerging Therapies Services team in the Greater Boston (MA) area is a part of Corporate Research Group and is engaged in the design, development, and optimization of iPSC engineering and manufacturing processes that can be transformed from early pre-clinical stage into cGMP ready manufacturing scale.

This is an exciting opportunity to drive the creation of new innovative biomanufacturing solutions. Sartorius has formed an initiative to discover new trends and cutting-edge opportunities for rapid conversion towards next generation continuous and integrated closed manufacturing solutions. This impactful initiative enables the research, process development and clinical production of novel modalities using next generation manufacturing platforms, in partnership with key customers.

As the Principal Scientist - Upstream Process Development, you will work closely with an internal multi-disciplinary product development team, to create forward looking processes that provide a basis for commercial manufacturing that can be integrated into our process solution offering.

What you will accomplish together with us:

• Design and optimize protocols for the culture and growth of primary cells and cell lines (e.g. HEK, CHO and Vero) using cutting-edge techniques aimed at enhancing the efficiency and scalability of the processes.
• Lead cross-functional teams, to scale primary cell and cell line expansion and from benchtop to production scale bioreactors.
• Develop and write process development proposals, conduct hands-on laboratory work to optimize and troubleshoot upstream manufacturing processes for Viral Vectors, mAbs and other biologics.
• Analyze and interpret data ensuring clear documentation of methodologies and outcomes.
• Prepare detailed reports and presentations for internal and external partners to communicate progress in line with project schedules.
• Assist in mentoring and training junior team members and coordinating the day-to-day operations.
• Lead and manage multiple high impact internal and external research projects by establishing priorities, milestones, schedules, and deadlines.
• Responsible for writing, reviewing, and maintaining electronic lab notebooks with the highest level of research integrity.
• Responsible for writing project reports, briefs, protocols and making presentations to internal and external partners and project teams as required.
• Lead technology transfer activities to internal and external collaborators.
• Support marketing efforts by writing technical briefs, application notes and peer reviewed publications, leading or assisting with technical presentations at scientific conferences.
• Conduct technical investigations and risk assessments related to processes.
• Support generation of protocols, work instructions, batch records and reports.
• Work independently in a matrixed environment.
• Perform occasional extended hours and weekends to support ongoing lab activities as needed.
• Mentor and support junior staff and build a culture of support and collaboration.
• Comply with all site policies such as record retention, ISO requirements, and accountable for good housekeeping in all laboratories.
• Comply with biohazard, special clean room and site safety/health procedures and guidelines as required.
• Assist other team members and site management team with miscellaneous duties when requested.

What will convince us:

Education:

• Ph.D. (with 6+ years of industry experience) in chemical, biochemical or biomedical engineering, engineered cell therapies or related field.

Experience:

• Extensive expertise in culturing cell types relevant to advanced therapy applications.
• Expertise in adapting existing cell culture processes from planar to 3D bioreactor systems.
• Hands-on experience with microcarrier-based suspension culture and single cell cloning is a plus.
• Knowledge of GxPs, experience in process development or GMP operation is a plus.
• Demonstrated ability to design, plan, and implement pluripotent cell differentiation protocols.
• Experience in the design and execution of current molecular biology and biochemical assay techniques including PCR, qPCR, ddPCR, NGS, WB, IF, ELISA, and Flow Cytometry is highly desirable.
• Experience & knowledge of state-of the-art upstream and downstream technologies for cell growth, transfection, propagation, and purification for application for process development workflow.
• Experience working as part of multi-partner R&D projects.
• Experience with documentation control systems.
• Familiarity with relevant guidelines from the FDA, EMA and ICH.

Working Conditions/Environment:

• Travel ~ 10-20% of time, both foreign and domestic. Work on weekends as required. Work in a Biosafety Level 2 Laboratory.

We value:

• Strong analytical and mathematical ability.
• Ability to work independently and constructively in a team environment.
• Must have strong personal initiative and be results oriented.
• Strong troubleshooting skills.
• Strong written and verbal English communication skills, capable of clearly expressing technical concepts to people with various levels of technical expertise and diverse cultural backgrounds.
• Identification with our core values: Sustainability, Openness, Enjoyment.

What We Offer

As a growing global life science company, with our stock listed on the German DAX and TecDAX, Sartorius offers a wide range of benefits:

• Personal and Professional Development: Mentoring, leadership programs, internal seminar offerings.
• Worklife Balance: Paid vacation, sick time, corporate holidays and community service day; as well as flexible work schedules.
• Making an Impact Right from the Start: Comprehensive onboarding, including a virtual online platform.
• Welcoming Culture: Mutual support, team spirit and international collaboration; communities on numerous topics such as “Coaching”, “Agile Working” and a “Businesswomen’s Network”.
• Health & Well Being: Wide selection of health and well-being support such as a variety of medical plans to choose from, dental, vision, EAP, and other wellness programs.
• Intelligent Working Environment: Working in smart buildings with the latest technology and equipment.

Retirement Savings Plan: 401 k (with generous company match).

Flexible Spending: HSA, FSA (dependent care & healthcare spending), Transportation Commuter Account.

Company Paid Benefits: Basic Life Insurance, AD&D, EAP, Family Planning & Women’s Health, Health Advocate.

Additional/Optional: Supplemental Life Insurance (employee, spouse & dependents), Legal Services, LTD & STD, Critical Illness Insurance, Student Loan Tuition Refinance Service.

All qualified applicants will be considered for employment without regard to race, color, religion, sex or national origin. We are also an equal opportunity employer of individuals with disabilities and protected veterans.

Sartorius is part of the solution in the fight against cancer, dementia, and many other diseases. Our technologies help translate scientific discoveries into real-world medicine faster, so that new therapeutics can reach patients worldwide. We look for ambitious team players and creative minds, who want to contribute to this goal and advance their careers in a dynamic global environment. Join our global team and become part of the solution. We are looking forward to receiving your application.

www.sartorius.com/career