Principal Scientist, Translational Oncology & Biomarkers

1000 Genentech, Inc.; South San Francisco (CA); Hybrid; USD 142.000 - 263.000; Vollzeit

Zusammenfassung

Genentech, a Roche company, seeks a Principal Scientist in Translational Medicine Oncology to bridge discovery research and clinical development. You will lead biomarker discovery and translational strategy across oncology programs, from first-in-human to registrational studies.

In this role, you will integrate multi-omic and spatial biology data, partner with computational biology, and contribute to regulatory submissions and trial protocols while mentoring teams and communicating complex

Qualifikationen

• Hold a PhD, MD, or MD/PhD with research excellence and first-author publications.
• Significant post-graduate industry or postdoctoral experience is required.
• Expertise in biomarker/translational methodologies (molecular profiling, multi-omics).
• Strong cross-functional collaboration and communication skills.
• Experience with translational oncology or clinical development preferred.
• Experience with machine learning and AI tools in translational discovery.

Aufgaben

• Design and drive end-to-end pharmacodynamic and predictive biomarker strategies across early- to late-stage studies.
• Identify novel biomarkers of response and mechanisms of resistance in translational studies.
• Integrate multi-omic, spatial biology, and single-cell data with computational biology teams.
• Lead biomarker and translational sections in protocols, submissions, and study reports.
• Collaborate across Research, Clinical Development, Biostatistics, Regulatory, and Clinical Operations.
• Provide scientific leadership for trial design and conduct with Operations.
• Engage with academic collaborators and KOLs; publish in high-impact venues.

Kenntnisse

Biomarker discovery

Translational research

Multi-omics integration

Single-cell genomics

Spatial biology

Computational biology

Cross-functional collaboration

Clinical development

Lung/colorectal cancer expertise

Machine learning in translational sci

Ausbildung

PhD/MD/MD-PhD in Molecular Biology, Cancer Biology, Immunology, Computational Biology, Bioinformatics, or related life sciences

Tools

R

Python

Jobbeschreibung

Genentech, a Roche company, seeks a Principal Scientist in Translational Medicine Oncology to bridge discovery research and clinical development. You will lead biomarker discovery and translational strategy across oncology programs, from first-in-human to registrational studies.

In this role, you will integrate multi-omic and spatial biology data, partner with computational biology, and contribute to regulatory submissions and trial protocols while mentoring teams and communicating complex