Principal Scientist, Peptide Chemistry - Lead Peptide Design

Calico Life Sciences; South San Francisco (CA); On-site; USD 197,000 - 220,000; Full time

Job summary

Calico Life Sciences seeks a Principal Scientist, Peptide Chemistry to join its Drug Discovery organization and to lead a team focused on peptide design, synthesis and engineering for research and drug development projects.

The successful candidate will collaborate with structural biologists, computational modellng scientists, medicinal chemists, DMPK and formulation scientists to explore structure-activity relationships and drive optimization, mentoring early career scientists and presenting

Qualifications

• Ph.D. in organic, medicinal, peptide, or biochemistry.
• 8+ years postdoctoral or equivalent in biopharma/biotech.
• Track record of high-profile publications desirable.

Responsibilities

• Lead peptide design, synthesis and engineering to support drug discovery.
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Skills

Protein–peptide interactions

Protein–small molecule interactions

Protein engineering

Assay development

Automation

Structure analysis software

Protein expression & purification

LC-MS / AS-MS

CRO management

Peptide synthesis & modification

Oral peptide bioavailability

Communication & teamwork

Education

Ph.D. in organic/medicinal/peptide/biochemistry

Tools

Chimera

PyMOL

Job description

Calico Life Sciences seeks a Principal Scientist, Peptide Chemistry to join its Drug Discovery organization and to lead a team focused on peptide design, synthesis and engineering for research and drug development projects.

The successful candidate will collaborate with structural biologists, computational modellng scientists, medicinal chemists, DMPK and formulation scientists to explore structure-activity relationships and drive optimization, mentoring early career scientists and presenting