Principal Scientist, Obesity Mechanisms & Targets

BioSpace; Lexington (MA); On-site; USD 180,000 - 235,000; Full time

Benefits offered by this job

Company bonus

Long‑term incentive compensation

Company vehicles

Job summary

Novo Nordisk in Massachusetts seeks a Principal Scientist to lead the Emerging Obesity Mechanisms portfolio, focusing on MASH and obesity‑related comorbidities, and to drive discovery through pre‑clinical and IND pathways.

You will mentor scientists, coordinate cross‑site biology activities, build MoA data packages, and collaborate with academia and industry while advancing translational models and human‑relevant systems.

Qualifications

• Bachelor’s degree required.
• 22+ years’ relevant experience required.
• Master’s Degree with 16 years relevant industry or post‑doctorate experience can be considered.
• PhD with 10 years relevant industry or post‑doctorate experience can be considered.
• Relevant required experience includes: small molecules and/or RNAi/siRNA modalities.

Responsibilities

• Lead target identification, validation and maturation of novel obesity‑comorbidity targets from idea generation through pre‑clinical and clinical‑stage gates across small‑molecule and RNAi/siRNA modalities.
• Build and strengthen MoA narratives and assemble data packages and screening plans for governance review to accelerate IND submission.
• Provide cross‑functional leadership, coordinating biology with pharmacology, omics, and other sites.
• Cultivate external collaborations to source targets/assets and extend capabilities across obesity comorbidities.
• Drive scientific communication through publications, conferences, and external collaborations.
• Mentor junior scientists toward autonomy and leadership in the obesity pipeline.

Skills

Small molecules

RNAi/siRNA

Leadership

Communication

Stakeholder management

Education

Bachelor's degree

Master’s degree

PhD

Job description

Novo Nordisk in Massachusetts seeks a Principal Scientist to lead the Emerging Obesity Mechanisms portfolio, focusing on MASH and obesity‑related comorbidities, and to drive discovery through pre‑clinical and IND pathways.

You will mentor scientists, coordinate cross‑site biology activities, build MoA data packages, and collaborate with academia and industry while advancing translational models and human‑relevant systems.