Principal Scientist, Multiomics
6084-Janssen Research & Development, LLC Legal Entity
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Benefits offered by this job
Job summary
Johnson & Johnson seeks a Principal Scientist in Cambridge, MA to lead advanced spatial omics and functional genomics initiatives. You will guide MPRA design, CRISPR-based screens, and integrated multiomic analyses across discovery programs, partnering with computational biology to translate data into therapeutic hypotheses.
The role requires a PhD with 6+ years in biotech/pharma, strong leadership, and expertise in spatial biology, genomics, and high-content screening.
Qualifications
- PhD in Genetics, Genomics, Molecular Biology, Systems Biology, Human Biology, Bioengineering, Computational Biology, or a related discipline. Postdoctoral training preferred.
- Minimum 6 years of biotech/pharma industry experience or equivalent translational research experience.
- Proven leadership with publications, presentations, or patents.
- Expertise across Spatial omics and functional genomics, including MPRAs or pooled screening.
- Experience in experimental design, assay development, and platform deployment.
- Ability to integrate multiomics data with biological insights.
Responsibilities
- Lead development and deployment of massively parallel reporter assays with spatial biology integration.
- Design workflows connecting perturbation data with spatial phenotypes.
- Collaborate with computational teams to build scalable analysis pipelines.
- Serve as scientific lead across discovery programs and external collaborations.
Skills
Education
Tools
Job description
At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.
Lead the development, optimization, and deployment of advanced massively parallel reporter assays and in combination with single cell and spatial omics across discovery programs. Design and implement innovative experimental workflows that integrate genetic perturbation, reporter assays, molecular profiling, and spatial analysis. Evaluate, establish, and scale emerging technologies that enhance therapeutic pathway discovery, mechanism‑of‑action studies, and translational research. Serve as a subject matter expert in spatial biology, functional genomics, and high‑content genomics screening technologies.
Design and execute workflows involving in situ hybridization, microscopy, spatial transcriptomics, spatial proteomics, high‑resolution imaging, and sequencing. Develop and optimize spatial assays using platforms such as Bruker CosMx, 10x Genomics Visium, Xenium, and emerging technologies. Apply spatial approaches to characterize cellular interactions, tissue architecture, disease mechanisms, and therapeutic responses.
Develop and deploy massively parallel reporter assays (MPRAs) to investigate protein elements, disease‑associated variants, transcriptional control mechanisms, and cell‑state specific regulatory programs. Design and execute pooled functional genomics studies, including CRISPR‑based perturbation screens, barcode‑enabled assays, and genetic screening workflows. Lead experimental design for library construction, vector engineering, cellular model generation, assay validation, and screening campaigns. Develop novel approaches that integrate perturbation, reporter activity, and transcriptional profiling within complex cellular systems. Familiarity with Antibody structure and Biologics Discovery is highly preferred.
Build workflows that connect functional perturbation data with spatial phenotypes and tissue‑level biology. Partner with computational scientists to develop data standards, quality‑control frameworks, and scalable analytical pipelines. Collaborate with platform and therapeutic area scientists to translate multiomic findings into actionable biological insights and therapeutic hypotheses.
- Education PhD in Genetics, Genomics, Molecular Biology, Systems Biology, Human Biology, Bioengineering, Computational Biology, or a related discipline. Postdoctoral training is preferred. Equivalent industry experience with a strong record of scientific achievement will also be considered.
- Required Minimum of 6 years of biotechnology or pharmaceutical industry experience, or equivalent experience in highly technical translational research environments.
- Demonstrated scientific leadership with a strong record of publications, presentations, patents, or major technology contributions.
- Deep expertise in at least one of the following domains, with demonstrated experience working across both: Spatial omics and molecular imaging technologies Functional genomics, pooled screening, and massively parallel reporter assays (MPRAs)
- Proven experience in experimental design, assay development, technology optimization, and platform deployment.
- Experience generating and interpreting complex multiomics datasets.
- Ability to work effectively across biology, technology, computational science, and therapeutic area teams.
- Strong written, verbal, and presentation skills.
- Demonstrated ability to apply innovative approaches to address complex biological questions.
- Experience with spatial transcriptomics, spatial proteomics, single‑cell genomics, or multimodal profiling technologies.
- Experience developing or applying MPRAs, CRISPR screens, Perturb‑seq, pooled screening technologies, or regulatory genomics approaches.
- Familiarity with genomics library design, barcode‑based assays, viral vector systems, and cell engineering.
- Experience with programming and data analysis in R and/or Python.
- Knowledge of neuroscience, oncology, immunology, or translational research applications.
- Experience managing multiple collaborations, external partners, and technology evaluations.
- Ability to serve as a scientific bridge between experimental and computational teams.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource. If you are under 18 years of age you (the candidate) may need to obtain the necessary working papers or other documentation required by state law to start the assignment, as well as get a parent’s consent for the background check.
Required Skills: Big Data Management, Critical Thinking, Data Reporting, Data Savvy, Drug Discovery Development, Molecular Diagnostics, Organizing, Pharmaceutical Microbiology, Problem Solving, Product Knowledge, Project Reporting, Project Schedule, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Standard Scientific Processes and Procedures, Strategic Thinking, Sustainability
Preferred Skills: Big Data Management, Critical Thinking, Data Reporting, Data Savvy, Drug Discovery Development, Molecular Diagnostics, Organizing, Pharmaceutical Microbiology, Problem Solving, Product Knowledge, Project Reporting, Project Schedule, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Standard Scientific Processes and Procedures, Strategic Thinking, Sustainability
The anticipated base pay range for this position is : $117,000.00 - $201,250.00
Additional Description for Pay Transparency: Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). This position is eligible to participate in the Company’s long‑term incentive program. Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:
- Vacation –120 hours per calendar year
- Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
- Holiday pay, including Floating Holidays –13 days per calendar year
- Work, Personal and Family Time - up to 40 hours per calendar year
- Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
- Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
- Caregiver Leave – 80 hours in a 52-week rolling period10 days
- Volunteer Leave – 32 hours per calendar year
- Military Spouse Time-Off – 80 hours per calendar year
For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits
At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at https://www.jnj.com/.
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